SESN2 (Sestrin 2) Gene
A stress-responsive gene involved in cellular homeostasis, aging, and cancer
Gene Information Card
| Symbol | SESN2 |
|---|---|
| Full Name | Sestrin 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1p35.3 |
| NCBI Gene ID | 83667 ncbi.nlm.nih.gov/gene/83667 |
| Ensembl ID | ENSG00000130766 |
| UniProt ID | P58004 |
| OMIM ID | 607767 |
| HGNC ID | 20746 |
| Aliases | SEST2, HI95, SES2 |
Description
SESN2 encodes sestrin 2, a stress-inducible protein that protects cells from oxidative stress, DNA damage, and metabolic dysregulation. It functions as a leucine sensor and regulates AMPK and mTORC1 signaling pathways, playing roles in aging, cancer, and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Non-small cell lung cancer | SESN2 downregulation promotes tumor growth via mTORC1 activation | PMID: 25605247 |
| Colorectal cancer | Reduced SESN2 expression correlates with poor prognosis and increased oxidative stress | PMID: 27323851 |
| Type 2 diabetes | SESN2 deficiency impairs insulin signaling and glucose homeostasis | PMID: 23395176 |
| Aging-related muscle atrophy | Loss of SESN2 accelerates sarcopenia through impaired autophagy | PMID: 29429943 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 10.2 | Medium |
| Skeletal muscle | 8.5 | Medium |
| Heart | 6.3 | Low |
| Kidney | 7.1 | Low |
| Lung | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 12.5 | Hepatocellular carcinoma cell line |
| A549 | 9.8 | Lung adenocarcinoma cell line |
| HEK293 | 7.3 | Embryonic kidney cells |
| MCF7 | 6.1 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.467C>T (p.Pro156Leu) | Missense | <0.01% | Unknown functional impact |
| c.1010G>A (p.Arg337Gln) | Missense | <0.01% | Reported in ClinVar as uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in germline; somatic loss in cancer may contribute to mTORC1 hyperactivation.
Gain of Function (GOF)
Not described.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process (GO:0006915) | • response to oxidative stress (GO:0006979) |
| • regulation of TOR signaling (GO:0032006) | • glucose homeostasis (GO:0042593) |
| • cytoplasm (GO:0005737) |
Pathways
• AMPK signaling pathway (Reactome: R-HSA-163285)
• mTORC1 signaling (Reactome: R-HSA-165159)
• Cellular response to stress (Reactome: R-HSA-2262752)
Protein Summary
Sestrin 2 is a 480-amino acid protein with a molecular weight of ~54 kDa. It contains a conserved sestrin domain and functions as a leucine sensor that inhibits mTORC1 and activates AMPK. It also exhibits oxidoreductase activity, reducing peroxiredoxins and protecting against oxidative damage.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SESN2 Knockout HEK293 Cell Line | EDJ-KQ1157 | Human | 83667 | Details Get a Quote |
| SESN2 Knockout A-549 Cell Line | EDJ-KQ19049 | Human | 83667 | Details Get a Quote |
| SESN2 Knockout HCT 116 Cell Line | EDJ-KQ20397 | Human | 83667 | Details Get a Quote |
| SESN2 Knockout HeLa Cell Line | EDJ-KQ20398 | Human | 83667 | Details Get a Quote |
