SERPINB2
Serpin Family B Member 2 (Plasminogen Activator Inhibitor Type 2)
Gene Information Card
| Symbol | SERPINB2 |
|---|---|
| Full Name | Serpin Family B Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 18q21.33 |
| NCBI Gene ID | 5055 ncbi.nlm.nih.gov/gene/5055 |
| Ensembl ID | ENSG00000197632 |
| UniProt ID | P05120 |
| OMIM ID | 173390 |
| HGNC ID | 8584 |
| Aliases | PAI-2, PAI2, PLANH2 |
Description
SERPINB2 (Serpin Family B Member 2) encodes plasminogen activator inhibitor type 2 (PAI-2), a member of the serpin family of serine protease inhibitors. PAI-2 inhibits urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), regulating fibrinolysis and extracellular matrix remodeling. It is primarily expressed in placenta, keratinocytes, and monocytes/macrophages, and is induced during inflammation and pregnancy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Placental insufficiency | Reduced PAI-2 levels impair fibrinolysis regulation, affecting placental development | PMID: 10683333 |
| Thrombophilia | PAI-2 deficiency may contribute to hyperfibrinolysis and bleeding disorders | ClinVar: 173390 |
| Cancer (e.g., breast, ovarian) | Overexpression of PAI-2 inhibits uPA-mediated invasion and metastasis | PMID: 10683333 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 125.3 | High |
| Skin | 45.6 | Medium |
| Lung | 12.8 | Low |
| Bone marrow | 8.4 | Low |
| Spleen | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| A549 | 22.1 | Lung carcinoma cell line |
| MCF7 | 5.8 | Breast cancer cell line |
| THP-1 | 35.4 | Monocytic leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Pro35Leu) | Missense | 0.01% | Reduced inhibitory activity |
| c.287G>A (p.Arg96His) | Missense | 0.005% | Unknown functional effect |
| c.1A>G (p.Met1Val) | Start loss | <0.001% | Loss of protein expression |
Mutation functional classification
Loss of Function (LOF)
Mutations that reduce or abolish PAI-2 inhibitory activity, such as p.Pro35Leu, are classified as loss-of-function.
Gain of Function (GOF)
No gain-of-function mutations have been reported in SERPINB2.
Dominant Negative (DN)
No dominant-negative mutations have been described for SERPINB2.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity | • plasminogen activator activity |
| • extracellular space | • cytoplasm |
| • response to lipopolysaccharide |
Pathways
• Plasminogen activating cascade
• Fibrinolysis
• uPAR-mediated signaling
Protein Summary
The SERPINB2 protein (PAI-2) is a 47 kDa serpin that inhibits uPA and tPA, thereby regulating plasmin generation. It exists in both intracellular and secreted forms, with the intracellular form lacking a signal peptide. PAI-2 is involved in tissue remodeling, inflammation, and protection against apoptosis. Its expression is upregulated by cytokines such as TNF-alpha and IL-1.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SERPINB2 Knockout HEK293 Cell Line | EDJ-KQ5398 | Human | 5055 | Details Get a Quote |
| SERPINB2 Knockout HeLa Cell Line | EDJ-KQ54075 | Human | 5055 | Details Get a Quote |
| SERPINB2 Knockout A-549 Cell Line | EDJ-KQ62563 | Human | 5055 | Details Get a Quote |
| SERPINB2 Knockout HCT 116 Cell Line | EDJ-KQ71033 | Human | 5055 | Details Get a Quote |
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