SERPINB11
Serpin Family B Member 11
Gene Information Card
| Symbol | SERPINB11 |
|---|---|
| Full Name | Serpin Family B Member 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 18q21.33 |
| NCBI Gene ID | 146198 ncbi.nlm.nih.gov/gene/146198 |
| Ensembl ID | ENSG00000186919 |
| UniProt ID | Q9BXR0 |
| OMIM ID | 616158 |
| HGNC ID | 23884 |
| Aliases | SERPINB11, serpin B11, MGC126616, MGC126618 |
Description
SERPINB11 (Serpin Family B Member 11) is a protein-coding gene located on chromosome 18q21.33. It belongs to the serpin family of serine protease inhibitors, though its specific inhibitory target remains unclear. The gene is expressed in various tissues and may play a role in regulating proteolysis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Lung | 2.1 | Low |
| Spleen | 1.8 | Low |
| Other tissues | <1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.5 | Low expression |
| HeLa | 0.3 | Low expression |
| K562 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity | • cytoplasm |
Pathways
• No known pathways
Protein Summary
SERPINB11 encodes a member of the serpin family, characterized by a conserved serpin domain. The protein is predicted to be a serine protease inhibitor, but its biological function and target protease remain unknown. It is expressed at low levels in a few tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SERPINB11 Knockout HEK293 Cell Line | EDJ-KQ10510 | Human | 89778 | Details Get a Quote |
| SERPINB11 Knockout HeLa Cell Line | EDJ-KQ57736 | Human | 89778 | Details Get a Quote |
| SERPINB11 Knockout A-549 Cell Line | EDJ-KQ66232 | Human | 89778 | Details Get a Quote |
| SERPINB11 Knockout HCT 116 Cell Line | EDJ-KQ74654 | Human | 89778 | Details Get a Quote |
