SERINC3: Serine Incorporator 3
A transmembrane protein involved in lipid metabolism, viral restriction, and potential tumor suppression.
Gene Information Card
| Symbol | SERINC3 |
|---|---|
| Full Name | serine incorporator 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 10955 ncbi.nlm.nih.gov/gene/10955 |
| Ensembl ID | ENSG00000132824 |
| UniProt ID | Q9NRX5 |
| OMIM ID | 614551 |
| HGNC ID | 30363 |
| Aliases | TDE1, TDE, SBBI99 |
Description
SERINC3 (serine incorporator 3) encodes a multi-pass transmembrane protein that facilitates the incorporation of serine into membrane phospholipids. It is involved in lipid metabolism, plasma membrane composition, and has been implicated in HIV-1 restriction by inhibiting viral fusion. The gene is also differentially expressed in various cancers, suggesting a role in tumor biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 infection (restriction) | SERINC3 incorporates into virions and inhibits HIV-1 fusion with target cells; counteracted by HIV-1 Nef protein. | PMID: 25774715, NCBI Gene |
| Colorectal cancer | Overexpression of SERINC3 (TDE1) observed in colorectal tumors; may promote cell proliferation. | PMID: 10652317, COSMIC |
| Lung cancer | Differential expression reported; potential tumor suppressor or oncogene depending on context. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lung | 8.2 | Medium |
| Colon | 7.1 | Medium |
| Brain | 5.3 | Low |
| Liver | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 10.5 | Moderate expression |
| A549 | 9.8 | Moderate expression |
| HCT 116 | 8.3 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497G>A (p.Arg166His) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.1034C>T (p.Pro345Leu) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.1234_1235insA | Frameshift | <0.01% | Predicted loss-of-function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants predicted to cause loss of SERINC3 protein function, potentially impairing serine incorporation and viral restriction.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in literature or curated databases.
Dominant Negative (DN)
No evidence of dominant-negative effects for SERINC3 mutations.
View complete mutation data：
Gene Ontology (GO)
| • serine incorporation into membrane phospholipid | • plasma membrane |
| • integral component of membrane | • viral restriction |
| • lipid metabolic process |
Pathways
• HIV-1 Nef-mediated evasion of host restriction
• Phospholipid biosynthesis
Protein Summary
SERINC3 is a 460-amino-acid transmembrane protein with 10-11 predicted membrane-spanning domains. It localizes to the plasma membrane and facilitates serine uptake for phosphatidylserine and sphingolipid synthesis. The protein is incorporated into HIV-1 virions and inhibits viral fusion, an effect counteracted by the HIV-1 Nef protein. SERINC3 is also upregulated in certain cancers, suggesting a role in cell proliferation and tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SERINC3 Knockout HEK293 Cell Line | EDJ-KQ7225 | Human | 10955 | Details Get a Quote |
| SERINC3 Knockout A-549 Cell Line | EDJ-KQ32191 | Human | 10955 | Details Get a Quote |
| SERINC3 Knockout HCT 116 Cell Line | EDJ-KQ32192 | Human | 10955 | Details Get a Quote |
| SERINC3 Knockout HeLa Cell Line | EDJ-KQ30817 | Human | 10955 | Details Get a Quote |
