SELL (Selectin L)
L-Selectin, CD62L, Lymph Node Homing Receptor
Gene Information Card
| Symbol | SELL |
|---|---|
| Full Name | Selectin L |
| Gene Type | Protein coding |
| Chromosomal Location | 1q24.2 |
| NCBI Gene ID | 6402 ncbi.nlm.nih.gov/gene/6402 |
| Ensembl ID | ENSG00000188404 |
| UniProt ID | P14151 |
| OMIM ID | 153395 |
| HGNC ID | 10720 |
| Aliases | CD62L, LAM1, LECAM1, LNHR, LSEL, TQ1, L-selectin |
Description
The SELL gene encodes L-selectin (CD62L), a cell adhesion molecule expressed on the surface of most leukocytes. L-selectin mediates the initial tethering and rolling of leukocytes on endothelial cells, facilitating their migration into lymphoid tissues and sites of inflammation. It is a key receptor for addressing on high endothelial venules and plays a critical role in lymphocyte homing, neutrophil recruitment, and immune surveillance.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Leukocyte Adhesion Deficiency Type II (LAD II) | Impaired fucosylation of selectin ligands reduces L-selectin binding, leading to defective leukocyte rolling and adhesion. | OMIM #266265 |
| Atherosclerosis | L-selectin-mediated leukocyte adhesion to activated endothelium contributes to plaque formation and progression. | NCBI Gene, PubMed |
| Sepsis | Shedding of L-selectin from neutrophils correlates with disease severity and organ dysfunction. | ClinVar, PubMed |
| Rheumatoid Arthritis | Elevated soluble L-selectin levels are associated with joint inflammation and disease activity. | PubMed |
| Multiple Sclerosis | L-selectin expression on T cells is altered in active disease, affecting CNS immune trafficking. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | High |
| Spleen | 10.8 | High |
| Bone marrow | 8.2 | Medium |
| Blood | 7.9 | Medium |
| Thymus | 6.5 | Medium |
| Lung | 2.1 | Low |
| Small intestine | 1.8 | Low |
| Colon | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.3 | High expression |
| Raji (Burkitt lymphoma) | 12.1 | High expression |
| THP-1 (monocytic leukemia) | 9.8 | Medium expression |
| K562 (chronic myeloid leukemia) | 3.2 | Low expression |
| HEK293 (embryonic kidney) | 0.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.499G>A (p.Gly167Arg) | Missense | <0.01% | Reduced ligand binding affinity; associated with altered immune cell trafficking. |
| c.763C>T (p.Arg255Cys) | Missense | <0.01% | Impaired shedding; potential link to inflammatory disorders. |
| c.1081G>A (p.Gly361Ser) | Missense | <0.01% | Decreased cell surface expression; reported in ClinVar. |
| c.1242_1243insA (p.Thr414Asnfs*12) | Frameshift | <0.01% | Loss of function; predicted to cause truncated protein. |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations leading to truncated or absent L-selectin protein, impairing leukocyte adhesion and homing.
Gain of Function (GOF)
Not well documented; some missense variants may increase ligand binding or shedding resistance, but evidence is limited.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported for SELL.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Leukocyte transendothelial migration (KEGG: hsa04670)
• Cell adhesion molecules (CAMs) (KEGG: hsa04514)
• Hematopoietic cell lineage (KEGG: hsa04640)
• T cell receptor signaling pathway (KEGG: hsa04660)
Protein Summary
L-selectin (CD62L) is a 372-amino acid transmembrane glycoprotein with an N-terminal C-type lectin domain, an EGF-like domain, two short consensus repeats (SCRs), a transmembrane region, and a short cytoplasmic tail. The lectin domain binds to sialyl Lewis X (sLeX) and related glycans on endothelial ligands such as GlyCAM-1, CD34, and MAdCAM-1. L-selectin is constitutively expressed on naive T cells, B cells, monocytes, and neutrophils, and is rapidly shed from the cell surface upon leukocyte activation via ADAM17-mediated proteolysis. Soluble L-selectin (sCD62L) is found in plasma and serves as a biomarker for immune activation and inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SELL Knockout HEK293 Cell Line | EDJ-KQ3271 | Human | 6402 | Details Get a Quote |
| SELL Knockout HCT 116 Cell Line | EDJ-KQ23433 | Human | 6402 | Details Get a Quote |
| SELL Knockout HeLa Cell Line | EDJ-KQ54439 | Human | 6402 | Details Get a Quote |
| SELL Knockout A-549 Cell Line | EDJ-KQ62930 | Human | 6402 | Details Get a Quote |
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