SELENOV Gene
Selenoprotein V: A Selenium-Containing Protein with Potential Roles in Redox Regulation and Cancer
Gene Information Card
| Symbol | SELENOV |
|---|---|
| Full Name | selenoprotein V |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 348303 ncbi.nlm.nih.gov/gene/348303 |
| Ensembl ID | ENSG00000187764 |
| UniProt ID | P59797 |
| OMIM ID | 607917 |
| HGNC ID | 30359 |
| Aliases | SELV, SELENOV1 |
Description
SELENOV (selenoprotein V) is a protein-coding gene located on chromosome 19q13.2. It encodes a selenoprotein containing a selenocysteine (Sec) residue encoded by the UGA codon. Selenoprotein V is expressed in various tissues and is thought to be involved in redox regulation and antioxidant defense. Its exact biological function is not fully characterized, but it may play a role in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential role in redox regulation; altered expression may contribute to tumorigenesis | COSMIC; limited direct evidence |
| Prostate cancer | Differential expression observed in prostate cancer tissues | NCBI Gene; PubMed studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Prostate | 1.5 | Low |
| Thyroid | 1.2 | Low |
| Adrenal gland | 0.9 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| HeLa | 0.6 | Low expression |
| MCF7 | 0.4 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337G>A (p.Gly113Arg) | Missense | <0.01% | Unknown; predicted benign |
| c.421T>C (p.Ser141Pro) | Missense | <0.01% | Unknown; predicted possibly damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • selenium binding (GO:0008430) |
| • oxidoreductase activity (GO:0016491) | • cell redox homeostasis (GO:0045454) |
Pathways
• Selenium metabolism and selenoprotein synthesis
• Redox regulation pathway
Protein Summary
Selenoprotein V is a small protein (approximately 15 kDa) containing a selenocysteine residue at position 33. It is predicted to be secreted or localized to the extracellular region. The protein may function as an oxidoreductase, participating in cellular redox balance. Its expression is low in most tissues, with highest levels in testis and prostate. The physiological role remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SELENOV Knockout HEK293 Cell Line | EDJ-KQ15219 | Human | 348303 | Details Get a Quote |
| SELENOV Knockout HeLa Cell Line | EDJ-KQ59836 | Human | 348303 | Details Get a Quote |
| SELENOV Knockout A-549 Cell Line | EDJ-KQ68302 | Human | 348303 | Details Get a Quote |
| SELENOV Knockout HCT 116 Cell Line | EDJ-KQ76675 | Human | 348303 | Details Get a Quote |
