SELENOO (Selenoprotein O): A Comprehensive Gene Resource
Explore the genomic, proteomic, and clinical significance of SELENOO, a mitochondrial selenoprotein implicated in oxidative stress and metabolic regulation.
Gene Information Card
| Symbol | SELENOO |
|---|---|
| Full Name | selenoprotein O |
| Gene Type | protein coding |
| Chromosomal Location | 22q13.33 |
| NCBI Gene ID | 83642 ncbi.nlm.nih.gov/gene/83642 |
| Ensembl ID | ENSG00000184293 |
| UniProt ID | Q9BVL4 |
| OMIM ID | 618803 |
| HGNC ID | 30479 |
| Aliases | SELO, dJ507I1.1 |
Description
SELENOO encodes selenoprotein O, a member of the selenoprotein family that contains a selenocysteine residue. It is localized to the mitochondria and plays a role in redox homeostasis and oxidative stress response. The protein has been implicated in AMPK signaling and may function as a protein kinase or pseudokinase, though its exact biochemical role is still under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect oxidative stress response and tumor progression. | COSMIC lists somatic mutations in multiple cancer types; expression changes observed in some studies. |
| Metabolic disorders | Potential involvement in AMPK signaling and energy metabolism. | Limited direct evidence; inferred from functional studies. |
| Neurodegenerative diseases | Oxidative stress is a common feature; SELENOO may modulate cellular defense. | No direct clinical association; speculative based on function. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 10.2 | Low |
| Liver | 8.5 | Low |
| Kidney | 7.9 | Low |
| Brain | 6.3 | Low |
| Testis | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.5 | Moderate expression |
| HepG2 | 9.8 | Low expression |
| A549 | 7.4 | Low expression |
| K562 | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Thr35Met) | Missense | 0.001% (gnomAD) | Unknown; predicted benign by in silico tools. |
| c.457G>A (p.Val153Ile) | Missense | 0.002% (gnomAD) | Unknown; no clinical significance reported. |
| c.789delC (p.Pro264LeufsTer5) | Frameshift | Rare | Predicted loss-of-function; may affect protein stability. |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations likely lead to reduced or absent protein function, impairing oxidative stress response.
Gain of Function (GOF)
No evidence for gain-of-function mutations in SELENOO.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • oxidoreductase activity | • selenium binding |
| • protein kinase activity | • mitochondrion |
| • response to oxidative stress | • ATP binding |
Pathways
• AMPK signaling pathway
• Selenocompound metabolism
• Response to oxidative stress
Protein Summary
Selenoprotein O is a 221-amino acid protein with a selenocysteine at position 44. It is localized to the mitochondria and contains a conserved domain resembling protein kinases. It is thought to play a role in redox regulation and may act as a pseudokinase, modulating AMPK activity. Its expression is ubiquitous but low across tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SELENOO Knockout HEK293 Cell Line | EDJ-KQ15217 | Human | 83642 | Details Get a Quote |
| SELENOO Knockout HeLa Cell Line | EDJ-KQ17988 | Human | 83642 | Details Get a Quote |
| SELENOO Knockout A-549 Cell Line | EDJ-KQ45874 | Human | 83642 | Details Get a Quote |
| SELENOO Knockout HCT 116 Cell Line | EDJ-KQ77989 | Human | 83642 | Details Get a Quote |
