SELENBP1: Selenium-Binding Protein 1
A key player in selenium metabolism, cellular redox regulation, and tumor suppression.
Gene Information Card
| Symbol | SELENBP1 |
|---|---|
| Full Name | Selenium-Binding Protein 1 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 8991 ncbi.nlm.nih.gov/gene/8991 |
| Ensembl ID | ENSG00000143365 |
| UniProt ID | Q13228 |
| OMIM ID | 604188 |
| HGNC ID | 10719 |
| Aliases | SP56, hSBP, SBP56, SELENBP1 |
Description
SELENBP1 encodes selenium-binding protein 1, a cytoplasmic protein that binds selenium and is involved in selenium transport, cellular redox homeostasis, and protein degradation. It is widely expressed and frequently downregulated in various cancers, suggesting a tumor-suppressive role. The protein interacts with the ubiquitin-proteasome system and may modulate oxidative stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Downregulation of SELENBP1 leads to increased oxidative stress and reduced apoptosis, promoting tumorigenesis. | ClinVar, COSMIC |
| Prostate Cancer | Loss of SELENBP1 expression correlates with poor prognosis and metastasis; selenium binding may affect androgen receptor signaling. | NCBI Gene, OMIM |
| Hepatocellular Carcinoma | Reduced SELENBP1 levels are associated with increased cell proliferation and invasion via altered redox balance. | COSMIC, literature |
| Breast Cancer | Epigenetic silencing of SELENBP1 contributes to chemoresistance and aggressive phenotype. | ClinVar, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 9.8 | Medium |
| Prostate | 7.2 | Low |
| Colon | 6.5 | Low |
| Lung | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.3 | Hepatocellular carcinoma cell line |
| LNCaP | 8.9 | Prostate cancer cell line |
| HT-29 | 6.7 | Colorectal adenocarcinoma cell line |
| MCF-7 | 4.2 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.586C>T (p.Arg196Trp) | Missense | <0.1% | Unknown functional impact; rare in population |
| c.1012G>A (p.Gly338Ser) | Missense | <0.1% | Reported in COSMIC; potential loss of function |
| c.1243C>T (p.Arg415*) | Nonsense | <0.1% | Premature truncation; likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein or reduced expression are associated with loss of tumor-suppressive activity.
Gain of Function (GOF)
No gain-of-function mutations reported for SELENBP1.
Dominant Negative (DN)
No dominant-negative mutations described for SELENBP1.
View complete mutation data：
Gene Ontology (GO)
| • selenium binding | • protein binding |
| • ubiquitin protein ligase binding | • oxidoreductase activity |
| • cytoplasm | • nucleus |
| • response to oxidative stress | • protein ubiquitination |
Pathways
• Selenium metabolism
• Ubiquitin-proteasome pathway
• Cellular response to oxidative stress
Protein Summary
Selenium-binding protein 1 (SBP56) is a 56 kDa cytoplasmic protein that binds selenium and participates in selenium transport and redox regulation. It interacts with the ubiquitin-proteasome system to modulate protein turnover and is implicated in tumor suppression. Downregulation of SELENBP1 is observed in multiple cancers, where it contributes to oxidative stress, proliferation, and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SELENBP1 Knockout HEK293 Cell Line | EDJ-KQ2334 | Human | 8991 | Details Get a Quote |
| SELENBP1 Knockout A-549 Cell Line | EDJ-KQ22736 | Human | 8991 | Details Get a Quote |
| SELENBP1 Knockout HeLa Cell Line | EDJ-KQ22737 | Human | 8991 | Details Get a Quote |
| SELENBP1 Knockout HCT 116 Cell Line | EDJ-KQ72002 | Human | 8991 | Details Get a Quote |
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