SECTM1 (Secreted and Transmembrane 1)
A cytokine-like protein involved in immune modulation and hematopoiesis.
Gene Information Card
| Symbol | SECTM1 |
|---|---|
| Full Name | Secreted and Transmembrane 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 63923 ncbi.nlm.nih.gov/gene/63923 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q8WXI7 |
| OMIM ID | 609084 |
| HGNC ID | 10707 |
| Aliases | K12 |
Description
SECTM1 (secreted and transmembrane 1) encodes a cytokine-like protein that exists in both secreted and transmembrane forms. It is involved in immune cell signaling, particularly in T-cell and monocyte activation, and plays a role in hematopoiesis and inflammatory responses. The gene is located on chromosome 17q25.3 and is primarily expressed in immune tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of SECTM1 may promote tumor growth and immune evasion through modulation of the tumor microenvironment. | PMID: 25605248 |
| Colorectal cancer | SECTM1 expression is upregulated and associated with poor prognosis, potentially via NF-κB pathway activation. | PMID: 29351289 |
| Inflammatory diseases | SECTM1 acts as a chemoattractant for monocytes and T cells, contributing to chronic inflammation. | PMID: 11564783 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lymph node | 6.7 | Low |
| Thymus | 5.1 | Low |
| Lung | 2.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocytic leukemia) | 15.2 | High expression |
| Jurkat (T-cell leukemia) | 9.8 | Medium expression |
| MCF7 (breast cancer) | 4.5 | Low expression |
| HEK293 (embryonic kidney) | 1.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236C>T (p.Pro79Leu) | Missense | <0.1% (gnomAD) | Unknown functional impact |
| c.421G>A (p.Gly141Arg) | Missense | <0.01% (gnomAD) | Predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in SECTM1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SECTM1.
Dominant Negative (DN)
No dominant-negative mutations reported in SECTM1.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity (GO:0005125) | • extracellular space (GO:0005615) |
| • integral component of membrane (GO:0016021) | • immune response (GO:0006955) |
| • signal transduction (GO:0007165) |
Pathways
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Hematopoietic cell lineage (KEGG: hsa04640)
Protein Summary
SECTM1 is a 248-amino-acid protein with a predicted N-terminal signal peptide, a transmembrane domain, and a C-terminal secreted region. It is synthesized as a type I transmembrane protein that can be proteolytically cleaved to release a soluble cytokine-like factor. The protein interacts with CD7 on T cells and monocytes, promoting cell adhesion and activation. Its expression is enriched in hematopoietic tissues and is dysregulated in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SECTM1 Knockout HEK293 Cell Line | EDJ-KQ3234 | Human | 6398 | Details Get a Quote |
| SECTM1 Knockout HCT 116 Cell Line | EDJ-KQ24745 | Human | 6398 | Details Get a Quote |
| SECTM1 Knockout HeLa Cell Line | EDJ-KQ24746 | Human | 6398 | Details Get a Quote |
| SECTM1 Knockout A-549 Cell Line | EDJ-KQ62927 | Human | 6398 | Details Get a Quote |
