SEC22B Gene: Vesicle Trafficking Protein SEC22b
SEC22B: A key regulator of ER-Golgi transport and immune surveillance
Gene Information Card
| Symbol | SEC22B |
|---|---|
| Full Name | SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) |
| Gene Type | protein-coding |
| Chromosomal Location | 1q21.2 |
| NCBI Gene ID | 9554 ncbi.nlm.nih.gov/gene/9554 |
| Ensembl ID | ENSG00000117407 |
| UniProt ID | O75396 |
| OMIM ID | 607345 |
| HGNC ID | 10700 |
| Aliases | SEC22L1, SEC22B1, ERS-24 |
Description
SEC22B encodes a member of the SEC22 family of vesicle trafficking proteins. It is a R-SNARE involved in endoplasmic reticulum (ER)-Golgi transport, autophagy, and phagocytosis. SEC22B is also implicated in cross-presentation of antigens in dendritic cells and plays a role in immune evasion by certain viruses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | SEC22B overexpression may promote tumor growth by enhancing vesicle trafficking and immune evasion. | COSMIC; PMID: 31073040 |
| Viral infections (e.g., influenza, SARS-CoV-2) | SEC22B is hijacked by viruses to facilitate viral entry and replication. | PMID: 32818467 |
| Neurodegenerative disorders | Dysregulation of SEC22B-mediated ER-Golgi transport may contribute to protein aggregation. | PMID: 29518349 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Liver | 10.2 | Medium |
| Kidney | 9.8 | Medium |
| Brain | 7.1 | Low |
| Heart | 6.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | High expression |
| HEK293 | 14.1 | High expression |
| A549 | 13.8 | High expression |
| HepG2 | 11.2 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.245C>T | missense | <0.1% | Reported in COSMIC; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair SNARE complex formation and vesicle fusion.
Gain of Function (GOF)
Not well characterized; overexpression in cancer may represent a gain-of-function phenotype.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • ER to Golgi vesicle-mediated transport | • SNARE binding |
| • autophagy | • phagocytosis |
| • intracellular protein transport |
Pathways
• ER-Golgi trafficking
• Autophagy
• Antigen cross-presentation
Protein Summary
SEC22B is a 250-amino acid R-SNARE protein localized to the ER-Golgi intermediate compartment. It forms SNARE complexes with syntaxin-5, GOSR1, and BET1L to mediate vesicle fusion. SEC22B also regulates autophagy by interacting with ATG9A and is critical for cross-presentation of exogenous antigens in dendritic cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SEC22B Knockout HEK293 Cell Line | EDJ-KQ6636 | Human | 9554 | Details Get a Quote |
| SEC22B Knockout A-549 Cell Line | EDJ-KQ30896 | Human | 9554 | Details Get a Quote |
| SEC22B Knockout HCT 116 Cell Line | EDJ-KQ30897 | Human | 9554 | Details Get a Quote |
| SEC22B Knockout HeLa Cell Line | EDJ-KQ30898 | Human | 9554 | Details Get a Quote |
