SEC11C: Signal Peptidase Complex Catalytic Subunit SEC11C
Essential component of the microsomal signal peptidase complex involved in protein translocation and processing in the endoplasmic reticulum.
Gene Information Card
| Symbol | SEC11C |
|---|---|
| Full Name | SEC11 homolog C, signal peptidase complex subunit |
| Gene Type | Protein coding |
| Chromosomal Location | 18q21.32 |
| NCBI Gene ID | 90701 ncbi.nlm.nih.gov/gene/90701 |
| Ensembl ID | ENSG00000166562 |
| UniProt ID | Q9BY50 |
| OMIM ID | 618447 |
| HGNC ID | 23483 |
| Aliases | SPC18, SEC11L3, HSPC192 |
Description
SEC11C encodes a catalytic subunit of the microsomal signal peptidase complex (SPC), which cleaves signal peptides from nascent proteins as they are translocated into the endoplasmic reticulum. This subunit is essential for the removal of signal peptides from a wide range of secretory and membrane proteins, enabling proper protein folding, sorting, and maturation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pan-cancer) | Altered SEC11C expression may affect processing of growth factor receptors and secreted oncoproteins, contributing to tumor progression. | COSMIC; TCGA data |
| Hepatocellular carcinoma | Upregulation of SEC11C correlates with poor prognosis; may enhance secretion of pro-tumorigenic factors. | PubMed; COSMIC |
| Breast cancer | SEC11C overexpression linked to increased cell proliferation and migration via altered protein secretion. | PubMed; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Pancreas | 10.8 | Medium |
| Kidney | 9.2 | Medium |
| Lung | 8.7 | Medium |
| Brain | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.3 | Hepatocellular carcinoma cell line |
| MCF7 | 11.0 | Breast cancer cell line |
| A549 | 9.5 | Lung cancer cell line |
| HEK293 | 8.2 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.1% | Unknown; predicted benign |
| c.412G>A (p.Gly138Arg) | Missense | <0.1% | Unknown; predicted possibly damaging |
| c.523C>T (p.Arg175Trp) | Missense | <0.1% | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in SEC11C.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SEC11C.
Dominant Negative (DN)
No dominant-negative mutations reported in SEC11C.
View complete mutation data：
Gene Ontology (GO)
| • endoplasmic reticulum (GO:0005783) | • signal peptidase complex (GO:0005787) |
| • signal peptide processing (GO:0006465) | • protein transport (GO:0015031) |
| • peptidase activity (GO:0008233) |
Pathways
• Signal Peptide Processing (Reactome: R-HSA-9013408)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
SEC11C is a 18 kDa catalytic subunit of the signal peptidase complex (SPC) located in the endoplasmic reticulum membrane. It contains a serine protease active site that cleaves signal peptides from precursor proteins during co-translational translocation. The protein is essential for the maturation of secretory and membrane proteins, and its dysregulation has been implicated in cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SEC11C Knockout HEK293 Cell Line | EDJ-KQ10633 | Human | 90701 | Details Get a Quote |
| SEC11C Knockout A-549 Cell Line | EDJ-KQ38132 | Human | 90701 | Details Get a Quote |
| SEC11C Knockout HCT 116 Cell Line | EDJ-KQ38133 | Human | 90701 | Details Get a Quote |
| SEC11C Knockout HeLa Cell Line | EDJ-KQ38134 | Human | 90701 | Details Get a Quote |
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