SEC11A: Signal Peptidase Complex Catalytic Subunit SEC11A
A key component of the signal peptidase complex involved in protein translocation and processing in the endoplasmic reticulum.
Gene Information Card
| Symbol | SEC11A |
|---|---|
| Full Name | SEC11 homolog A, signal peptidase complex catalytic subunit |
| Gene Type | protein-coding |
| Chromosomal Location | 15q25.3 |
| NCBI Gene ID | 23478 ncbi.nlm.nih.gov/gene/23478 |
| Ensembl ID | ENSG00000137822 |
| UniProt ID | P67812 |
| OMIM ID | 612086 |
| HGNC ID | 23478 |
| Aliases | SPC18, SEC11, SEC11L1, SPCS4A |
Description
SEC11A encodes a catalytic subunit of the signal peptidase complex (SPC), which is located in the endoplasmic reticulum (ER) membrane. The SPC cleaves signal peptides from nascent proteins as they are translocated into the ER, a critical step in protein maturation and secretion. SEC11A is ubiquitously expressed and plays a role in cellular homeostasis and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pancreatic, breast, lung) | Overexpression of SEC11A may enhance processing of growth factor receptors and oncoproteins, promoting tumor growth. | PMID: 25691885, 29367642 |
| Hepatocellular carcinoma | SEC11A upregulation correlates with poor prognosis and increased proliferation. | PMID: 31065034 |
| Colorectal cancer | SEC11A expression is elevated and associated with metastasis. | PMID: 31570863 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 25.6 | High |
| Liver | 18.3 | High |
| Breast | 12.1 | Medium |
| Lung | 14.7 | Medium |
| Brain | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.4 | Cervical cancer cell line |
| MCF7 | 18.9 | Breast cancer cell line |
| A549 | 20.1 | Lung cancer cell line |
| HepG2 | 27.3 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.01% | Unknown functional impact |
| c.412C>T (p.Arg138Trp) | Missense | <0.01% | Potential loss of function |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare missense and start-loss variants may impair signal peptidase activity, affecting protein processing.
Gain of Function (GOF)
Not reported in SEC11A.
Dominant Negative (DN)
Not reported in SEC11A.
View complete mutation data：
Gene Ontology (GO)
| • endoplasmic reticulum (GO:0005783) | • signal peptide processing (GO:0006465) |
| • signal peptidase complex (GO:0005787) | • peptidase activity (GO:0008233) |
| • integral component of membrane (GO:0016021) |
Pathways
• Signal Peptide Processing (Reactome: R-HSA-9609507)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
SEC11A (SPC18) is a 178-amino acid catalytic subunit of the signal peptidase complex. It contains a serine protease active site (Ser-91, His-133, Asp-153) and is embedded in the ER membrane. The protein cleaves signal peptides from pre-proteins, enabling proper folding and trafficking. SEC11A is overexpressed in several cancers and is considered a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SEC11A Knockout HEK293 Cell Line | EDJ-KQ8026 | Human | 23478 | Details Get a Quote |
| SEC11A Knockout A-549 Cell Line | EDJ-KQ33806 | Human | 23478 | Details Get a Quote |
| SEC11A Knockout HCT 116 Cell Line | EDJ-KQ33807 | Human | 23478 | Details Get a Quote |
| SEC11A Knockout HeLa Cell Line | EDJ-KQ33808 | Human | 23478 | Details Get a Quote |
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