SDF4 (Stromal Cell Derived Factor 4)
Calcium-binding protein involved in protein secretion and calcium homeostasis
Gene Information Card
| Symbol | SDF4 |
|---|---|
| Full Name | Stromal Cell Derived Factor 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 51150 ncbi.nlm.nih.gov/gene/51150 |
| Ensembl ID | ENSG00000117525 |
| UniProt ID | Q9BRK5 |
| OMIM ID | 614403 |
| HGNC ID | 10679 |
| Aliases | CAB45, SDF-4, FLJ11029 |
Description
SDF4 (Stromal Cell Derived Factor 4) encodes a calcium-binding protein localized to the Golgi apparatus. It is involved in calcium homeostasis and protein secretion, particularly in the sorting and packaging of secretory proteins. The protein contains multiple EF-hand domains that bind calcium ions, regulating its function in the secretory pathway.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered SDF4 expression may influence tumor microenvironment and metastasis via calcium signaling | COSMIC, NCBI Gene |
| Pancreatic cancer | SDF4 overexpression associated with poor prognosis and tumor progression | COSMIC, PubMed (via NCBI) |
| Ovarian cancer | Differential expression observed in tumor vs normal tissue | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Breast | 10.3 | Medium |
| Pancreas | 8.7 | Low |
| Liver | 6.2 | Low |
| Brain | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| PANC-1 (pancreatic cancer) | 12.8 | High expression |
| HeLa (cervical cancer) | 9.5 | Medium expression |
| HEK293 (embryonic kidney) | 7.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | <0.1% | Unknown functional impact |
| c.512C>T (p.Thr171Met) | Missense | <0.1% | Unknown functional impact |
| c.724_725insA | Frameshift | <0.1% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.724_725insA) likely result in truncated protein and loss of calcium-binding function.
Gain of Function (GOF)
No gain-of-function mutations reported in SDF4.
Dominant Negative (DN)
No dominant-negative mutations reported in SDF4.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
• Calcium signaling pathway (KEGG: hsa04020)
Protein Summary
SDF4 is a 45 kDa calcium-binding protein predominantly localized to the Golgi lumen. It contains four EF-hand motifs that bind Ca2+ with high affinity, enabling it to regulate calcium-dependent protein sorting and secretion. The protein is ubiquitously expressed, with highest levels in secretory tissues such as breast and pancreas. It plays a role in maintaining Golgi calcium homeostasis and facilitating the transport of secretory cargo.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SDF4 Knockout HEK293 Cell Line | EDJ-KQ2783 | Human | 51150 | Details Get a Quote |
| SDF4 Knockout A-549 Cell Line | EDJ-KQ23701 | Human | 51150 | Details Get a Quote |
| SDF4 Knockout HCT 116 Cell Line | EDJ-KQ23702 | Human | 51150 | Details Get a Quote |
| SDF4 Knockout HeLa Cell Line | EDJ-KQ23703 | Human | 51150 | Details Get a Quote |
