SDF2: Stromal Cell-Derived Factor 2
A gene encoding a secreted protein involved in endoplasmic reticulum stress response and protein quality control.
Gene Information Card
| Symbol | SDF2 |
|---|---|
| Full Name | Stromal Cell-Derived Factor 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 6388 ncbi.nlm.nih.gov/gene/6388 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q99470 |
| OMIM ID | 602934 |
| HGNC ID | 10676 |
| Aliases | SDF-2, MGC111102 |
Description
SDF2 (Stromal Cell-Derived Factor 2) is a protein-coding gene located on chromosome 17q11.2. The encoded protein is a secreted factor that plays a role in the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress. It is involved in protein quality control and may modulate cellular responses to ER stress. SDF2 is broadly expressed in many tissues and is implicated in various cancers and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diabetes Mellitus Type 2 | SDF2 expression is altered in pancreatic islets under ER stress, potentially affecting insulin secretion. | PMID: 21880731 |
| Colorectal Cancer | SDF2 is upregulated in colorectal tumors and may contribute to tumor progression via ER stress modulation. | PMID: 25605247 |
| Breast Cancer | SDF2 expression correlates with poor prognosis and may promote metastasis through UPR activation. | PMID: 29187742 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Kidney | 6.7 | Low |
| Colon | 10.1 | Medium |
| Breast | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line; high expression |
| HepG2 | 11.8 | Hepatocellular carcinoma cell line |
| MCF7 | 9.5 | Breast cancer cell line |
| A549 | 8.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287C>T (p.Pro96Leu) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.412G>A (p.Gly138Ser) | Missense | <0.01% | Unknown; predicted possibly damaging by PolyPhen |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in SDF2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SDF2.
Dominant Negative (DN)
No dominant-negative mutations reported for SDF2.
View complete mutation data：
Gene Ontology (GO)
| • endoplasmic reticulum (GO:0005783) | • extracellular region (GO:0005576) |
| • response to endoplasmic reticulum stress (GO:0034976) | • response to unfolded protein (GO:0006986) |
Pathways
• Unfolded Protein Response (UPR) - Reactome R-HSA-381119
• Endoplasmic Reticulum Stress Pathway - KEGG hsa04141
Protein Summary
The SDF2 protein is a 211-amino acid secreted factor with a signal peptide. It localizes to the endoplasmic reticulum and extracellular space. SDF2 is induced by ER stress and interacts with components of the UPR, such as BiP/GRP78. It may function as a chaperone or signaling molecule to alleviate ER stress and maintain protein homeostasis. The protein is glycosylated and contains a conserved domain of unknown function (DUF).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SDF2L1 Knockout HEK293 Cell Line | EDJ-KQ1080 | Human | 23753 | Details Get a Quote |
| SDF2 Knockout HEK293 Cell Line | EDJ-KQ5733 | Human | 6388 | Details Get a Quote |
| SDF2 Knockout A-549 Cell Line | EDJ-KQ29119 | Human | 6388 | Details Get a Quote |
| SDF2 Knockout HCT 116 Cell Line | EDJ-KQ29120 | Human | 6388 | Details Get a Quote |
| SDF2 Knockout HeLa Cell Line | EDJ-KQ29121 | Human | 6388 | Details Get a Quote |
| SDF2L1 Knockout A-549 Cell Line | EDJ-KQ20219 | Human | 23753 | Details Get a Quote |
| SDF2L1 Knockout HCT 116 Cell Line | EDJ-KQ20220 | Human | 23753 | Details Get a Quote |
| SDF2L1 Knockout HeLa Cell Line | EDJ-KQ20221 | Human | 23753 | Details Get a Quote |
