SDCBP2
Syndecan Binding Protein 2
Gene Information Card
| Symbol | SDCBP2 |
|---|---|
| Full Name | syndecan binding protein 2 |
| Gene Type | protein coding |
| Chromosomal Location | 20p13 |
| NCBI Gene ID | 27111 ncbi.nlm.nih.gov/gene/27111 |
| Ensembl ID | ENSG00000101412 |
| UniProt ID | Q9H190 |
| OMIM ID | 617359 |
| HGNC ID | 30486 |
| Aliases | Syntenin-2, ST-2, ST2 |
Description
SDCBP2 (syndecan binding protein 2) encodes a member of the syntenin protein family. The protein contains two PDZ domains and binds to the cytoplasmic domain of syndecans, playing a role in cytoskeletal organization, vesicular trafficking, and cell signaling. It is involved in exosome biogenesis and may influence cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of SDCBP2 may promote tumor cell migration and invasion via syndecan-mediated signaling | COSMIC, literature |
| Prostate cancer | Altered expression linked to metastatic potential; PDZ domain interactions affect cell adhesion | COSMIC, literature |
| Melanoma | SDCBP2 expression changes correlate with tumor progression and exosome secretion | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 15.2 | Medium |
| Testis | 20.7 | High |
| Ovary | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.4 | Moderate expression |
| HeLa | 14.2 | Moderate expression |
| MCF7 | 22.1 | High expression |
| A549 | 11.5 | Low expression |
| K562 | 7.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347G>A (p.Arg116Gln) | Missense | <0.1% | Unknown functional effect |
| c.523C>T (p.Pro175Ser) | Missense | <0.1% | Unknown functional effect |
| c.789_790insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.789_790insA) likely result in truncated protein and loss of PDZ domain function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • PDZ domain binding |
| • cytoskeleton | • cytoplasmic vesicle |
| • cell junction | • exosome |
Pathways
• Syndecan-mediated signaling
• Exosome biogenesis and secretion
• Cell adhesion and migration
Protein Summary
SDCBP2 (Syntenin-2) is a 291-amino acid protein with two PDZ domains. It localizes to the cytoplasm and plasma membrane, interacting with syndecans and other transmembrane proteins. It regulates exosome production, cytoskeletal dynamics, and cell adhesion. Overexpression in certain cancers suggests a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SDCBP2 Knockout HEK293 Cell Line | EDJ-KQ8682 | Human | 27111 | Details Get a Quote |
| SDCBP2 Knockout HCT 116 Cell Line | EDJ-KQ34884 | Human | 27111 | Details Get a Quote |
| SDCBP2 Knockout HeLa Cell Line | EDJ-KQ56002 | Human | 27111 | Details Get a Quote |
| SDCBP2 Knockout A-549 Cell Line | EDJ-KQ64490 | Human | 27111 | Details Get a Quote |
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