SDCBP (Syndecan Binding Protein) Gene
A scaffold protein involved in exosome biogenesis, cell adhesion, and cancer progression
Gene Information Card
| Symbol | SDCBP |
|---|---|
| Full Name | Syndecan Binding Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 8q12.1 |
| NCBI Gene ID | 6386 ncbi.nlm.nih.gov/gene/6386 |
| Ensembl ID | ENSG00000137575 |
| UniProt ID | O00560 |
| OMIM ID | 602217 |
| HGNC ID | 10662 |
| Aliases | MDA-9, ST1, SYCL, syntenin, pro-TGF-alpha-cytoplasmic domain-interacting protein 18 |
Description
SDCBP (syndecan binding protein), also known as syntenin or MDA-9, encodes a scaffold protein that binds to the cytoplasmic domain of syndecans. It plays a key role in exosome biogenesis, cell adhesion, cytoskeletal organization, and intracellular trafficking. SDCBP is overexpressed in multiple cancers and is implicated in tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | SDCBP overexpression promotes invasion and metastasis via NF-κB and FAK signaling | PMID: 23934199 |
| Breast cancer | SDCBP enhances exosome secretion and tumor cell migration | PMID: 30523278 |
| Glioma | SDCBP supports cell proliferation and invasion through PDZ domain interactions | PMID: 25605248 |
| Hepatocellular carcinoma | SDCBP upregulation correlates with poor prognosis and metastasis | PMID: 27840973 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 32.5 | High |
| Breast | 28.1 | High |
| Brain | 15.3 | Medium |
| Liver | 12.7 | Medium |
| Heart | 8.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 45.2 | High expression |
| A549 (lung cancer) | 38.6 | High expression |
| U87MG (glioma) | 29.4 | Medium expression |
| HepG2 (liver cancer) | 22.1 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.1% | Unknown functional impact |
| c.487G>A (p.Gly163Ser) | Missense | <0.1% | Reported in COSMIC; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in SDCBP.
Gain of Function (GOF)
Overexpression and amplification are associated with oncogenic gain-of-function in multiple cancers.
Dominant Negative (DN)
No dominant-negative mutations characterized.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • plasma membrane (GO:0005886) |
| • protein transport (GO:0015031) | • secretory granule (GO:0030141) |
| • membrane raft (GO:0045121) | • extracellular exosome (GO:0070062) |
Pathways
• Exosome biogenesis and secretion
• Syndecan-mediated signaling
• Cell adhesion and migration
• NF-κB signaling pathway
Protein Summary
SDCBP encodes syntenin, a 298-amino acid PDZ domain-containing scaffold protein. It localizes to the plasma membrane and endosomal compartments, where it links syndecans to cytoskeletal and signaling molecules. Syntenin is critical for exosome production and is frequently upregulated in cancers, promoting invasion and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SDCBP Knockout HEK293 Cell Line | EDJ-KQ3106 | Human | 6386 | Details Get a Quote |
| SDCBP2 Knockout HEK293 Cell Line | EDJ-KQ8682 | Human | 27111 | Details Get a Quote |
| SDCBP Knockout A-549 Cell Line | EDJ-KQ23059 | Human | 6386 | Details Get a Quote |
| SDCBP Knockout HCT 116 Cell Line | EDJ-KQ24438 | Human | 6386 | Details Get a Quote |
| SDCBP Knockout HeLa Cell Line | EDJ-KQ24439 | Human | 6386 | Details Get a Quote |
| SDCBP2 Knockout HCT 116 Cell Line | EDJ-KQ34884 | Human | 27111 | Details Get a Quote |
| SDCBP2 Knockout HeLa Cell Line | EDJ-KQ56002 | Human | 27111 | Details Get a Quote |
| SDCBP2 Knockout A-549 Cell Line | EDJ-KQ64490 | Human | 27111 | Details Get a Quote |
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