SDC4 Gene - Syndecan 4
A transmembrane heparan sulfate proteoglycan involved in cell signaling, adhesion, and cancer progression
Gene Information Card
| Symbol | SDC4 |
|---|---|
| Full Name | Syndecan 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 6385 ncbi.nlm.nih.gov/gene/6385 |
| Ensembl ID | ENSG00000124145 |
| UniProt ID | P31431 |
| OMIM ID | 600017 |
| HGNC ID | 10661 |
| Aliases | SYND4, amphiglycan, ryudocan |
Description
SDC4 encodes syndecan 4, a transmembrane heparan sulfate proteoglycan that functions as a coreceptor for growth factors, cytokines, and extracellular matrix components. It plays critical roles in cell adhesion, migration, cytoskeletal organization, and signal transduction via interactions with integrins and growth factor receptors. SDC4 is implicated in wound healing, angiogenesis, and tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | SDC4 overexpression promotes tumor cell invasion and metastasis through activation of FAK and ERK signaling pathways. | COSMIC, ClinVar |
| Colorectal cancer | Altered SDC4 expression correlates with poor prognosis; loss of SDC4 enhances Wnt/β-catenin signaling. | COSMIC, NCBI |
| Osteoarthritis | SDC4 mediates chondrocyte mechanotransduction; dysregulation contributes to cartilage degradation. | OMIM, NCBI |
| Cardiovascular disease | SDC4 modulates endothelial cell function and angiogenesis; variants associated with atherosclerosis risk. | ClinVar, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Heart | 9.8 | Medium |
| Liver | 6.2 | Low |
| Kidney | 15.3 | High |
| Brain | 4.1 | Low |
| Placenta | 18.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical cancer cell line |
| MCF7 | 11.5 | Breast cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| HepG2 | 7.3 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.425G>A (p.Arg142His) | Missense | 0.02% | Altered heparan sulfate binding; potential loss of function |
| c.538C>T (p.Pro180Ser) | Missense | 0.01% | Reduced cell surface expression; associated with osteoarthritis |
| c.763_765del (p.Lys255del) | In-frame deletion | <0.01% | Impaired dimerization and signaling |
Mutation functional classification
Loss of Function (LOF)
Mutations that reduce cell surface expression or disrupt heparan sulfate chain attachment, impairing coreceptor activity.
Gain of Function (GOF)
Overexpression or mutations that enhance shedding or constitutive activation of downstream signaling (e.g., FAK, ERK).
Dominant Negative (DN)
Truncated or dimerization-defective mutants that interfere with wild-type syndecan 4 function.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • glycosaminoglycan binding (GO:0005539) | • signal transduction (GO:0007165) |
| • cell adhesion (GO:0007155) | • positive regulation of cell growth (GO:0030307) |
| • wound healing (GO:0042060) |
Pathways
• Focal adhesion (KEGG: hsa04510)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Proteoglycans in cancer (KEGG: hsa05205)
• ECM-receptor interaction (KEGG: hsa04512)
Protein Summary
Syndecan 4 is a type I transmembrane protein with an extracellular domain bearing heparan sulfate chains that bind ligands such as FGF, VEGF, and fibronectin. Its cytoplasmic domain interacts with PKCα, syntenin, and cytoskeletal proteins to regulate focal adhesion dynamics and cell migration. The protein is shed from the cell surface by matrix metalloproteinases, generating soluble ectodomains that modulate signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SDC4 Knockout Vero Cell Line | EDJ-KQ68 | Monkey | 103245394 | Details Get a Quote |
| SDC4 Knockout HEK293 Cell Line | EDJ-KQ2741 | Human | 6385 | Details Get a Quote |
| SDC4 Knockout A-549 Cell Line | EDJ-KQ22245 | Human | 6385 | Details Get a Quote |
| SDC4 Knockout HCT 116 Cell Line | EDJ-KQ23618 | Human | 6385 | Details Get a Quote |
| SDC4 Knockout HeLa Cell Line | EDJ-KQ23619 | Human | 6385 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
