SDC2 (Syndecan 2)
A transmembrane heparan sulfate proteoglycan involved in cell signaling, matrix organization, and cancer progression
Gene Information Card
| Symbol | SDC2 |
|---|---|
| Full Name | Syndecan 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q22.1 |
| NCBI Gene ID | 6383 ncbi.nlm.nih.gov/gene/6383 |
| Ensembl ID | ENSG00000169439 |
| UniProt ID | P34741 |
| OMIM ID | 142461 |
| HGNC ID | 10659 |
| Aliases | SYND2, HSPG, CD362 |
Description
SDC2 encodes syndecan 2, a transmembrane heparan sulfate proteoglycan that functions as a coreceptor for growth factors, cytokines, and extracellular matrix components. It plays critical roles in cell adhesion, migration, cytoskeletal organization, and angiogenesis. SDC2 is frequently overexpressed in colorectal cancer and is used as a DNA methylation biomarker for early detection.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | SDC2 promoter hypermethylation silences gene expression; loss contributes to tumor progression | ClinVar, COSMIC |
| Breast cancer | Overexpression of SDC2 correlates with poor prognosis and metastasis | NCBI Gene, PubMed |
| Gastric cancer | Aberrant SDC2 methylation detected in tumor tissues and liquid biopsies | ClinVar |
| Osteoarthritis | SDC2 regulates chondrocyte differentiation and matrix remodeling | OMIM |
| Angiogenesis disorders | SDC2 modulates VEGF signaling and endothelial cell migration | UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 6.7 | Low |
| Liver | 4.2 | Low |
| Kidney | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HCT116 (colorectal) | 15.2 | High expression |
| MCF7 (breast) | 7.8 | Moderate expression |
| A549 (lung) | 5.4 | Low expression |
| HEK293 (embryonic kidney) | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown effect |
| c.245C>T | Nonsense | <0.1% | Predicted loss of function |
| c.789_790insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in SDC2 are predicted to truncate the protein, impairing heparan sulfate attachment and receptor function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SDC2.
Dominant Negative (DN)
No evidence for dominant-negative SDC2 mutations.
View complete mutation data：
Gene Ontology (GO)
| • heparan sulfate proteoglycan binding | • extracellular matrix binding |
| • growth factor binding | • cell adhesion |
| • angiogenesis | • cytoskeleton organization |
Pathways
• VEGF signaling pathway
• FGF signaling pathway
• Integrin signaling pathway
• ECM-receptor interaction
Protein Summary
Syndecan 2 is a type I transmembrane protein with an extracellular domain carrying heparan sulfate chains that bind ligands such as FGF, VEGF, and fibronectin. The cytoplasmic domain interacts with PDZ-domain proteins (e.g., syntenin) to regulate cytoskeletal dynamics and signal transduction. Post-translational modifications include glycosylation and proteolytic shedding.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SDC2 Knockout HEK293 Cell Line | EDJ-KQ2299 | Human | 6383 | Details Get a Quote |
| CSDC2 Knockout HEK293 Cell Line | EDJ-KQ8736 | Human | 27254 | Details Get a Quote |
| SDC2 Knockout HeLa Cell Line | EDJ-KQ24038 | Human | 6383 | Details Get a Quote |
| CSDC2 Knockout A-549 Cell Line | EDJ-KQ34981 | Human | 27254 | Details Get a Quote |
| CSDC2 Knockout HeLa Cell Line | EDJ-KQ33718 | Human | 27254 | Details Get a Quote |
| SDC2 Knockout A-549 Cell Line | EDJ-KQ62924 | Human | 6383 | Details Get a Quote |
| SDC2 Knockout HCT 116 Cell Line | EDJ-KQ71394 | Human | 6383 | Details Get a Quote |
| CSDC2 Knockout HCT 116 Cell Line | EDJ-KQ72985 | Human | 27254 | Details Get a Quote |
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