SDC1 (Syndecan 1)
A key cell surface proteoglycan involved in cell adhesion, growth factor signaling, and cancer progression.
Gene Information Card
| Symbol | SDC1 |
|---|---|
| Full Name | Syndecan 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 2p24.1 |
| NCBI Gene ID | 6382 ncbi.nlm.nih.gov/gene/6382 |
| Ensembl ID | ENSG00000115884 |
| UniProt ID | P18827 |
| OMIM ID | 186355 |
| HGNC ID | 10658 |
| Aliases | CD138, SDC, syndecan |
Description
SDC1 encodes syndecan 1, a transmembrane heparan sulfate proteoglycan that functions as a co-receptor for growth factors, cytokines, and extracellular matrix components. It is involved in cell proliferation, adhesion, and migration. SDC1 is a well-established marker for plasma cells and is frequently dysregulated in multiple myeloma and other cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Multiple Myeloma | Overexpression of SDC1 (CD138) on malignant plasma cells promotes cell survival and adhesion in the bone marrow microenvironment. Shedding of the ectodomain correlates with poor prognosis. | ClinVar, COSMIC, NCBI |
| Breast Cancer | Altered SDC1 expression influences tumor growth and metastasis through modulation of growth factor signaling (e.g., FGF, VEGF). | NCBI, COSMIC |
| Lung Cancer | SDC1 overexpression is associated with increased invasiveness and poor survival in non-small cell lung cancer. | COSMIC, NCBI |
| Hepatocellular Carcinoma | SDC1 expression changes affect cell adhesion and Wnt signaling, contributing to tumor progression. | NCBI, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Plasma cells (bone marrow) | High | High |
| Skin | Moderate | Medium |
| Lung | Low | Low |
| Liver | Low | Low |
| Kidney | Low | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| RPMI-8226 (multiple myeloma) | High | Plasma cell line; high SDC1 expression |
| U266 (multiple myeloma) | High | Plasma cell line; high SDC1 expression |
| MCF7 (breast cancer) | Moderate | Epithelial line; variable expression |
| A549 (lung cancer) | Low | Low expression in this line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Potential loss of function; uncertain significance |
| c.100G>A (p.Gly34Arg) | Missense | Rare | Unknown effect; reported in COSMIC |
| c.500T>C (p.Leu167Pro) | Missense | Rare | Unknown effect; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in SDC1 are rare and not well characterized; they may impair cell adhesion and signaling.
Gain of Function (GOF)
Gain-of-function is typically associated with overexpression rather than specific activating mutations.
Dominant Negative (DN)
No dominant-negative mutations have been reported for SDC1.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005578 - proteinaceous extracellular matrix | • GO:0005886 - plasma membrane |
| • GO:0005539 - glycosaminoglycan binding | • GO:0008201 - heparin binding |
| • GO:0007165 - signal transduction | • GO:0007155 - cell adhesion |
Pathways
• Heparan sulfate proteoglycan biosynthesis
• FGF signaling pathway
• VEGF signaling pathway
• Wnt signaling pathway
• Integrin signaling pathway
Protein Summary
Syndecan 1 (CD138) is a type I transmembrane heparan sulfate proteoglycan. The core protein (310 amino acids) has an extracellular domain with attachment sites for heparan sulfate and chondroitin sulfate chains, a single transmembrane domain, and a short cytoplasmic tail. It mediates cell-cell and cell-matrix adhesion, acts as a co-receptor for growth factors (e.g., FGF, VEGF), and modulates signaling pathways. Shedding of the ectodomain by matrix metalloproteinases releases soluble syndecan 1, which can regulate tumor microenvironment.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BSDC1 Knockout HEK293 Cell Line | EDJ-KQ12570 | Human | 55108 | Details Get a Quote |
| SDC1 Knockout HEK293 Cell Line | EDJ-KQ17716 | Human | 6382 | Details Get a Quote |
| SDC1 Knockout A-549 Cell Line | EDC07920 | Human | 6382 | Details Get a Quote |
| SDC1 Knockout HCT 116 Cell Line | EDJ-KQ19788 | Human | 6382 | Details Get a Quote |
| SDC1 Knockout HeLa Cell Line | EDJ-KQ19789 | Human | 6382 | Details Get a Quote |
| BSDC1 Knockout A-549 Cell Line | EDJ-KQ41590 | Human | 55108 | Details Get a Quote |
| BSDC1 Knockout HCT 116 Cell Line | EDJ-KQ41591 | Human | 55108 | Details Get a Quote |
| BSDC1 Knockout HeLa Cell Line | EDJ-KQ41592 | Human | 55108 | Details Get a Quote |
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