SCUBE2
Signal peptide, CUB domain and EGF-like domain-containing protein 2
Gene Information Card
| Symbol | SCUBE2 |
|---|---|
| Full Name | Signal peptide, CUB domain and EGF-like domain-containing protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.3 |
| NCBI Gene ID | 57758 ncbi.nlm.nih.gov/gene/57758 |
| Ensembl ID | ENSG00000175356 |
| UniProt ID | Q9NQ36 |
| OMIM ID | 611746 |
| HGNC ID | 30424 |
| Aliases | CEGP1, MEGF2 |
Description
SCUBE2 encodes a member of the SCUBE (signal peptide, CUB domain, and EGF-like domain) family of secreted and membrane-associated proteins. The protein contains an N-terminal signal peptide, multiple EGF-like repeats, a CUB domain, and a C-terminal cysteine-rich region. It is involved in hedgehog signaling, angiogenesis, and cell adhesion. SCUBE2 is expressed in various tissues and has been implicated in cancer progression and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | SCUBE2 overexpression promotes tumor growth and metastasis via hedgehog pathway activation | PMID: 21362587 |
| Prostate cancer | SCUBE2 enhances androgen receptor signaling and cell proliferation | PMID: 25605247 |
| Hepatocellular carcinoma | SCUBE2 upregulation correlates with poor prognosis and epithelial-mesenchymal transition | PMID: 27323851 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Liver | 8.7 | Medium |
| Kidney | 15.2 | Medium |
| Lung | 6.4 | Low |
| Breast | 9.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 11.5 | Breast cancer cell line |
| HepG2 | 14.2 | Hepatocellular carcinoma cell line |
| PC3 | 8.9 | Prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | 0.02% | p.Pro412Ser; uncertain significance |
| c.567G>A | missense | 0.01% | p.Val189Met; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in SCUBE2.
Gain of Function (GOF)
Overexpression of SCUBE2 is associated with oncogenic signaling in several cancers.
Dominant Negative (DN)
No dominant-negative mutations described for SCUBE2.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding | • heparin binding |
| • extracellular matrix structural constituent | • cell adhesion |
| • angiogenesis | • hedgehog signaling pathway |
Pathways
• Hedgehog signaling pathway
• Cell adhesion molecules (CAMs)
Protein Summary
SCUBE2 is a secreted and membrane-associated glycoprotein that modulates hedgehog signaling and cell adhesion. It contains EGF-like repeats and a CUB domain, facilitating interactions with extracellular matrix components and receptors. The protein is implicated in tumor progression and developmental morphogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCUBE2 Knockout HEK293 Cell Line | EDJ-KQ15194 | Human | 57758 | Details Get a Quote |
| SCUBE2 Knockout HeLa Cell Line | EDJ-KQ56913 | Human | 57758 | Details Get a Quote |
| SCUBE2 Knockout A-549 Cell Line | EDJ-KQ65421 | Human | 57758 | Details Get a Quote |
| SCUBE2 Knockout HCT 116 Cell Line | EDJ-KQ73858 | Human | 57758 | Details Get a Quote |
