SCTR Gene: Secretin Receptor - Structure, Function, and Clinical Significance
A comprehensive overview of the SCTR gene, encoding the secretin receptor, including genomic information, expression patterns, associated diseases, and mutation landscape.
Gene Information Card
| Symbol | SCTR |
|---|---|
| Full Name | Secretin receptor |
| Gene Type | protein coding |
| Chromosomal Location | 2q14.1 |
| NCBI Gene ID | 6344 ncbi.nlm.nih.gov/gene/6344 |
| Ensembl ID | ENSG00000109861 |
| UniProt ID | P47872 |
| OMIM ID | 182098 |
| HGNC ID | 10610 |
| Aliases | SR, MGC119477, MGC119479 |
Description
The SCTR gene encodes the secretin receptor, a G protein-coupled receptor (GPCR) for the hormone secretin. It is a member of the class B (secretin family) of GPCRs. The receptor is primarily expressed in tissues such as the pancreas, gastrointestinal tract, and brain. Upon binding secretin, the receptor activates adenylate cyclase, increasing intracellular cAMP levels, which regulates pancreatic bicarbonate secretion, bile secretion, and other digestive processes. SCTR is also involved in cell proliferation and differentiation, and its dysregulation has been implicated in various cancers and gastrointestinal disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic ductal adenocarcinoma | Loss of SCTR expression is associated with tumor progression and poor prognosis; secretin signaling may inhibit tumor growth. | PMID: 25652204; COSMIC |
| Gastric cancer | Reduced SCTR expression is linked to increased cell proliferation and invasion; secretin may act as a tumor suppressor. | PMID: 27381357 |
| Cholangiocarcinoma | SCTR expression is downregulated in malignant bile duct cells, affecting secretin-induced apoptosis and proliferation. | PMID: 23149915 |
| Inflammatory bowel disease | SCTR variants may influence susceptibility to Crohn's disease and ulcerative colitis via altered immune responses. | ClinVar; PMID: 28067908 |
| Diabetes mellitus | SCTR is expressed in pancreatic beta cells; secretin enhances glucose-stimulated insulin secretion, and SCTR dysfunction may impair insulin release. | PMID: 24614135 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | High | High |
| Duodenum | High | High |
| Stomach | Medium | Medium |
| Liver | Low | Low |
| Brain | Medium | Medium |
| Kidney | Low | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic cancer) | Low | SCTR expression is reduced in pancreatic cancer cell lines. |
| MIA PaCa-2 (pancreatic cancer) | Low | Low expression compared to normal pancreatic cells. |
| HCT116 (colorectal cancer) | Medium | Moderate expression; secretin may affect cell growth. |
| HepG2 (hepatocellular carcinoma) | Low | Low expression in liver cancer cells. |
| Caco-2 (intestinal) | High | High expression; used for secretin signaling studies. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1138C>T (p.Arg380Cys) | Missense | Rare | May affect receptor signaling; reported in ClinVar. |
| c.1042G>A (p.Val348Ile) | Missense | Rare | Potential impact on ligand binding; not well characterized. |
| c.1234A>G (p.Thr412Ala) | Missense | Rare | Reported in COSMIC; functional significance unknown. |
| c.1472C>T (p.Pro491Leu) | Missense | Rare | May alter receptor conformation; observed in cancer samples. |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in SCTR are not well documented; however, reduced expression or inactivating variants may impair secretin signaling, leading to decreased cAMP production and altered digestive secretion.
Gain of Function (GOF)
No gain-of-function mutations have been reported for SCTR.
Dominant Negative (DN)
No dominant-negative mutations have been described for SCTR.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • secretin receptor activity |
| • peptide hormone binding | • plasma membrane |
| • integral component of membrane | • adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| • cAMP-mediated signaling | • positive regulation of cAMP biosynthetic process |
| • response to peptide hormone | • digestion |
Pathways
• Class B GPCR signaling
• cAMP/PKA signaling pathway
• Secretin signaling pathway
• GPCR downstream signaling
Protein Summary
The secretin receptor is a 428-amino acid protein with seven transmembrane domains, characteristic of GPCRs. It has a large extracellular N-terminal domain involved in ligand binding. The receptor couples to Gs proteins, activating adenylate cyclase and increasing intracellular cAMP. This leads to activation of protein kinase A (PKA) and downstream effects on ion channels and gene expression. The receptor is critical for pancreatic bicarbonate secretion and bile secretion. Post-translational modifications include glycosylation and phosphorylation, which modulate receptor activity and desensitization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCTR Knockout HEK293 Cell Line | EDJ-KQ5725 | Human | 6344 | Details Get a Quote |
| SCTR Knockout HeLa Cell Line | EDJ-KQ54410 | Human | 6344 | Details Get a Quote |
| SCTR Knockout A-549 Cell Line | EDJ-KQ62899 | Human | 6344 | Details Get a Quote |
| SCTR Knockout HCT 116 Cell Line | EDJ-KQ71366 | Human | 6344 | Details Get a Quote |
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