SCT (Secretin) Gene
Secretin Gene - Neuroendocrine Hormone and Gastrointestinal Regulator
Gene Information Card
| Symbol | SCT |
|---|---|
| Full Name | Secretin |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 6343 ncbi.nlm.nih.gov/gene/6343 |
| Ensembl ID | ENSG00000109920 |
| UniProt ID | P09683 |
| OMIM ID | 182100 |
| HGNC ID | 10607 |
| Aliases | SCT, secretin |
Description
The SCT gene encodes secretin, a 27-amino acid peptide hormone primarily produced by S cells in the duodenum. Secretin regulates gastric acid secretion, pancreatic bicarbonate secretion, and water homeostasis. It is also expressed in the brain and acts as a neuropeptide. The gene is located on chromosome 11p15.5 and contains 4 exons.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Zollinger-Ellison Syndrome | Elevated secretin levels due to gastrinoma; secretin stimulation test used for diagnosis | ClinVar, OMIM |
| Pancreatic Exocrine Insufficiency | Reduced secretin release impairs bicarbonate secretion | NCBI Gene, OMIM |
| Autism Spectrum Disorder | Secretin administration studied for gastrointestinal symptoms; limited evidence | ClinVar, PubMed |
| Duodenal Ulcer | Altered secretin response affects gastric acid neutralization | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Duodenum | 112.3 | High |
| Small Intestine | 45.6 | Medium |
| Pancreas | 8.2 | Low |
| Brain (Hypothalamus) | 3.1 | Low |
| Stomach | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HuTu-80 (Duodenal) | 89.4 | High expression |
| Caco-2 (Colorectal) | 12.7 | Moderate expression |
| SH-SY5Y (Neuroblastoma) | 4.3 | Low expression |
| HeLa (Cervical) | 1.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional effect |
| c.79C>T | Nonsense | <0.01% | Premature truncation, loss of function |
| c.101G>A | Missense | <0.01% | Reduced peptide stability |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.79C>T) lead to truncated secretin peptide, impairing hormone activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • hormone activity (GO:0005179) | • extracellular region (GO:0005576) |
| • plasma membrane (GO:0005886) | • regulation of hormone secretion (GO:0010817) |
| • positive regulation of insulin secretion (GO:0032024) | • glucose homeostasis (GO:0042593) |
Pathways
• Secretin receptor signaling pathway (Reactome: R-HSA-420092)
• G alpha(s) signaling events (Reactome: R-HSA-388396)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
Secretin is a 27-amino acid peptide hormone (UniProt P09683) synthesized as a preproprotein of 120 residues. After cleavage of the signal peptide and further processing, the mature secretin is secreted. It binds to the secretin receptor (SCTR), a G protein-coupled receptor, activating adenylate cyclase and increasing cAMP. Secretin stimulates pancreatic bicarbonate secretion, inhibits gastric acid secretion, and modulates water and electrolyte balance in the intestine. It also acts as a neuropeptide in the central nervous system.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCTR Knockout HEK293 Cell Line | EDJ-KQ5725 | Human | 6344 | Details Get a Quote |
| SCT Knockout HEK293 Cell Line | EDJ-KQ50612 | Human | 6343 | Details Get a Quote |
| SCT Knockout HeLa Cell Line | EDJ-KQ54409 | Human | 6343 | Details Get a Quote |
| SCTR Knockout HeLa Cell Line | EDJ-KQ54410 | Human | 6344 | Details Get a Quote |
| SCT Knockout A-549 Cell Line | EDJ-KQ62898 | Human | 6343 | Details Get a Quote |
| SCTR Knockout A-549 Cell Line | EDJ-KQ62899 | Human | 6344 | Details Get a Quote |
| SCT Knockout HCT 116 Cell Line | EDJ-KQ71365 | Human | 6343 | Details Get a Quote |
| SCTR Knockout HCT 116 Cell Line | EDJ-KQ71366 | Human | 6344 | Details Get a Quote |
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