SCRN3 Gene - Secernin 3
Comprehensive gene card for SCRN3 (secernin 3) including genomic data, expression, mutations, and disease associations.
Gene Information Card
| Symbol | SCRN3 |
|---|---|
| Full Name | secernin 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 79668 ncbi.nlm.nih.gov/gene/79668 |
| Ensembl ID | ENSG00000144381 |
| UniProt ID | Q7Z7G1 |
| OMIM ID | 617799 |
| HGNC ID | 30395 |
| Aliases | SES3, FLJ22662 |
Description
SCRN3 (secernin 3) is a protein-coding gene located on chromosome 2q31.1. It belongs to the secernin family, which is involved in exocytosis and cellular signaling. The encoded protein may play a role in secretory processes and has been implicated in cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may influence tumor progression | COSMIC, literature |
| Breast cancer | Differential expression observed in tumor vs normal tissue | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| MCF7 | 14.3 | Medium expression |
| A549 | 9.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437G>A (p.Arg146His) | Missense | <0.01% | Unknown |
| c.1024C>T (p.Arg342Trp) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • exocytosis | • protein binding |
| • cytoplasm | • membrane |
Pathways
• Exocytosis
• Vesicle-mediated transport
Protein Summary
Secernin 3 is a 456-amino acid protein localized to the cytoplasm and membrane. It is involved in exocytosis and may regulate secretory granule fusion. The protein contains a conserved secernin domain and is expressed in multiple tissues, with highest levels in testis and brain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCRN3 Knockout HEK293 Cell Line | EDJ-KQ15193 | Human | 79634 | Details Get a Quote |
| SCRN3 Knockout A-549 Cell Line | EDJ-KQ47993 | Human | 79634 | Details Get a Quote |
| SCRN3 Knockout HCT 116 Cell Line | EDJ-KQ47994 | Human | 79634 | Details Get a Quote |
| SCRN3 Knockout HeLa Cell Line | EDJ-KQ47995 | Human | 79634 | Details Get a Quote |
