SCRN2 Gene - Secernin 2
Comprehensive gene information for SCRN2, including expression, mutations, and associated diseases.
Gene Information Card
| Symbol | SCRN2 |
|---|---|
| Full Name | secernin 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.33 |
| NCBI Gene ID | 90507 ncbi.nlm.nih.gov/gene/90507 |
| Ensembl ID | ENSG00000167978 |
| UniProt ID | Q96MF2 |
| OMIM ID | 617502 |
| HGNC ID | 30399 |
| Aliases | FLJ20607, SES2 |
Description
SCRN2 (secernin 2) is a protein-coding gene located on chromosome 17q21.33. It encodes a member of the secernin family, which is involved in exocytosis and may play a role in cellular secretion processes. The protein is expressed in various tissues and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may affect exocytosis and cell signaling | COSMIC database reports mutations in various cancers |
| Breast cancer | Overexpression linked to tumor progression | PubMed studies (PMID: 25691885) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 15.2 | Medium |
| Testis | 20.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 18.4 | High expression |
| HeLa | 14.2 | Medium expression |
| A549 | 9.8 | Low expression |
| MCF7 | 22.1 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347G>A (p.Arg116His) | Missense | 0.02% | Unknown functional impact |
| c.502C>T (p.Arg168Cys) | Missense | 0.01% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • exocytosis (GO:0006887) | • membrane (GO:0016020) |
| • cytoplasm (GO:0005737) |
Pathways
• Exocytosis pathway (Reactome: R-HSA-5653656)
Protein Summary
Secernin 2 is a 462-amino acid protein involved in exocytosis. It localizes to the cytoplasm and membrane, and may regulate secretion in various cell types. Its expression is elevated in testis and certain cancer cell lines.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCRN2 Knockout HEK293 Cell Line | EDJ-KQ10608 | Human | 90507 | Details Get a Quote |
| SCRN2 Knockout A-549 Cell Line | EDJ-KQ38096 | Human | 90507 | Details Get a Quote |
| SCRN2 Knockout HCT 116 Cell Line | EDJ-KQ38097 | Human | 90507 | Details Get a Quote |
| SCRN2 Knockout HeLa Cell Line | EDJ-KQ38098 | Human | 90507 | Details Get a Quote |
