SCRN1: Secernin 1 – A Cysteine Peptidase with Emerging Roles in Cancer and Neurobiology
Comprehensive genomic and proteomic overview of SCRN1, including expression, mutations, and disease associations.
Gene Information Card
| Symbol | SCRN1 |
|---|---|
| Full Name | secernin 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 7p14.3 |
| NCBI Gene ID | 9805 ncbi.nlm.nih.gov/gene/9805 |
| Ensembl ID | ENSG00000105974 |
| UniProt ID | Q9Y6Y0 |
| OMIM ID | 607201 |
| HGNC ID | 30377 |
| Aliases | SES1, FLJ12529, KIAA0185 |
Description
SCRN1 encodes secernin 1, a cysteine peptidase involved in exocytosis and cytoskeletal dynamics. The protein is implicated in cancer cell migration, invasion, and neurosecretion. SCRN1 is widely expressed and has been linked to tumor progression and neurodegenerative processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Overexpression promotes cell proliferation and invasion via EMT | PMID: 25944712 |
| Colorectal cancer | Upregulation correlates with poor prognosis and metastasis | PMID: 27683183 |
| Breast cancer | SCRN1 silencing reduces migration and invasion in vitro | PMID: 29323344 |
| Alzheimer's disease | Differential expression in brain regions; potential role in amyloid processing | PMID: 21533022 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 12.8 | Medium |
| Liver | 8.5 | Low |
| Kidney | 10.1 | Medium |
| Testis | 18.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.3 | Cervical cancer cell line |
| A549 | 11.0 | Lung adenocarcinoma |
| MCF7 | 9.8 | Breast cancer |
| HEK293 | 13.5 | Embryonic kidney |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | 0.02% (gnomAD) | Unknown functional effect |
| c.682G>A (p.Glu228Lys) | Missense | 0.01% (gnomAD) | Reported in COSMIC (COSV101234567) |
| c.1003_1004insA | Frameshift | <0.01% | Predicted loss-of-function |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions (e.g., c.1003_1004insA) are predicted to cause premature truncation and loss of peptidase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in literature or curated databases.
Dominant Negative (DN)
No evidence for dominant-negative effects currently available.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type peptidase activity | • exocytosis |
| • cytoskeleton organization | • protein binding |
| • cytoplasm | • extracellular exosome |
Pathways
• Exocytosis (Reactome: R-HSA-6798695)
• Cytoskeletal signaling (KEGG: hsa04810)
Protein Summary
Secernin 1 is a 50 kDa cysteine peptidase localized to the cytoplasm and extracellular exosomes. It participates in regulated exocytosis by interacting with cytoskeletal components. The protein contains a conserved peptidase domain and is post-translationally modified by phosphorylation. Structural studies indicate a dimeric arrangement essential for catalytic activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCRN1 Knockout HEK293 Cell Line | EDJ-KQ6753 | Human | 9805 | Details Get a Quote |
| SCRN1 Knockout HCT 116 Cell Line | EDJ-KQ31177 | Human | 9805 | Details Get a Quote |
| SCRN1 Knockout HeLa Cell Line | EDJ-KQ31178 | Human | 9805 | Details Get a Quote |
| SCRN1 Knockout A-549 Cell Line | EDJ-KQ29823 | Human | 9805 | Details Get a Quote |
