SCG5: Secretogranin V (7B2 Protein) – A Key Neuroendocrine Chaperone
Comprehensive genomic and proteomic analysis of SCG5, a regulator of prohormone convertase 2 (PC2) activity.
Gene Information Card
| Symbol | SCG5 |
|---|---|
| Full Name | Secretogranin V |
| Gene Type | Protein coding |
| Chromosomal Location | 15q13.3 |
| NCBI Gene ID | 6447 ncbi.nlm.nih.gov/gene/6447 |
| Ensembl ID | ENSG00000166965 |
| UniProt ID | P05408 |
| OMIM ID | 600042 |
| HGNC ID | 10599 |
| Aliases | 7B2, SgV, SGNE1 |
Description
SCG5 (secretogranin V) encodes the neuroendocrine protein 7B2, a chaperone that binds and activates prohormone convertase 2 (PC2). It is expressed in endocrine and neural tissues and plays a critical role in the processing of peptide hormones and neuropeptides. Mutations in SCG5 can disrupt PC2 activity and have been linked to metabolic and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Impaired PC2 activation leads to defective prohormone processing (e.g., proopiomelanocortin) | ClinVar, OMIM |
| Diabetes mellitus (type 2) | Altered insulin and glucagon processing due to PC2 dysfunction | NCBI Gene, OMIM |
| Neuroendocrine tumors | Overexpression of SCG5 as a biomarker for neuroendocrine differentiation | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pituitary | 45.2 | High |
| Pancreas | 32.1 | High |
| Brain (cortex) | 18.7 | Medium |
| Adrenal gland | 22.5 | Medium |
| Liver | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 28.4 | Neuronal model |
| INS-1 (insulinoma) | 35.6 | Pancreatic beta-cell model |
| HeLa | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.214C>T (p.Arg72Cys) | Missense | 0.01% | Reduced PC2 binding affinity |
| c.389G>A (p.Gly130Asp) | Missense | 0.005% | Impaired chaperone function |
| c.1A>G (p.Met1?) | Start loss | Rare | Loss of protein expression |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Arg72Cys) reduce PC2 activation, leading to defective prohormone processing.
Gain of Function (GOF)
Not reported for SCG5.
Dominant Negative (DN)
Not reported for SCG5.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • Golgi apparatus (GO:0005794) |
| • cytoplasmic vesicle (GO:0031410) | • perinuclear region of cytoplasm (GO:0048471) |
| • unfolded protein binding (GO:0051082) |
Pathways
• Prohormone processing (PC2 activation)
• Neuroendocrine secretion
Protein Summary
Secretogranin V (7B2) is a 212-amino acid neuroendocrine chaperone that binds to prohormone convertase 2 (PC2) in the Golgi apparatus, facilitating its transport and activation. It is essential for the proteolytic processing of numerous prohormones, including proopiomelanocortin, proinsulin, and proglucagon. The protein is stored in secretory granules and released upon stimulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCG5 Knockout HEK293 Cell Line | EDJ-KQ50625 | Human | 6447 | Details Get a Quote |
| SCG5 Knockout HeLa Cell Line | EDJ-KQ54458 | Human | 6447 | Details Get a Quote |
| SCG5 Knockout A-549 Cell Line | EDJ-KQ62945 | Human | 6447 | Details Get a Quote |
| SCG5 Knockout HCT 116 Cell Line | EDJ-KQ71417 | Human | 6447 | Details Get a Quote |
