SCG2 (Secretogranin II)
A neuroendocrine secretory protein involved in hormone packaging and neurotransmission
Gene Information Card
| Symbol | SCG2 |
|---|---|
| Full Name | Secretogranin II |
| Gene Type | protein-coding |
| Chromosomal Location | 2q36.1 |
| NCBI Gene ID | 7857 ncbi.nlm.nih.gov/gene/7857 |
| Ensembl ID | ENSG00000171951 |
| UniProt ID | P13521 |
| OMIM ID | 118930 |
| HGNC ID | 10570 |
| Aliases | CHGB, SgII, secretogranin-2 |
Description
SCG2 encodes secretogranin II, a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is involved in the packaging and sorting of peptide hormones and neurotransmitters into secretory vesicles. The protein is cleaved to produce bioactive peptides such as secretoneurin, which has chemotactic and angiogenic properties.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroendocrine tumors | Overexpression of SCG2 is associated with neuroendocrine differentiation; secretoneurin promotes tumor angiogenesis | PMID: 12368274 |
| Schizophrenia | SCG2 polymorphisms have been linked to altered risk; secretoneurin may modulate neurotransmission | PMID: 18382116 |
| Cardiovascular disease | Secretoneurin levels are elevated in heart failure and correlate with disease severity | PMID: 22615329 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Pituitary gland | 8.3 | Medium |
| Adrenal gland | 6.7 | Medium |
| Pancreas | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | High expression; used in neurosecretion studies |
| HeLa (cervical carcinoma) | 0.8 | Low expression |
| HEK293 (embryonic kidney) | 1.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.416C>T (p.Pro139Leu) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.728G>A (p.Arg243Gln) | Missense | <0.01% | Unknown; rare variant in population databases |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in SCG2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SCG2.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • extracellular space (GO:0005615) |
| • secretory granule (GO:0030141) | • metal ion binding (GO:0046872) |
| • hormone activity (GO:0005179) |
Pathways
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
• Regulation of exocytosis (Reactome: R-HSA-422085)
Protein Summary
Secretogranin II is a 617-amino-acid acidic glycoprotein stored in large dense-core vesicles of neuroendocrine cells. It undergoes proteolytic processing to generate secretoneurin and other peptides. Secretoneurin acts as a chemokine for monocytes and endothelial cells, promoting angiogenesis and inflammation. The protein is widely used as a marker for neuroendocrine differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCG2 Knockout HEK293 Cell Line | EDJ-KQ2021 | Human | 7857 | Details Get a Quote |
| SCG2 Knockout A-549 Cell Line | EDJ-KQ22047 | Human | 7857 | Details Get a Quote |
| SCG2 Knockout HCT 116 Cell Line | EDJ-KQ22048 | Human | 7857 | Details Get a Quote |
| SCG2 Knockout HeLa Cell Line | EDJ-KQ20750 | Human | 7857 | Details Get a Quote |
