SCARF1
Scavenger Receptor Class F Member 1
Gene Information Card
| Symbol | SCARF1 |
|---|---|
| Full Name | Scavenger Receptor Class F Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 8578 ncbi.nlm.nih.gov/gene/8578 |
| Ensembl ID | ENSG00000108379 |
| UniProt ID | Q14162 |
| OMIM ID | 607873 |
| HGNC ID | 10569 |
| Aliases | SREC-I, SREC1, SR-F1 |
Description
SCARF1 (scavenger receptor class F member 1) encodes a type I transmembrane glycoprotein that functions as a scavenger receptor. It mediates the binding and internalization of modified low-density lipoproteins (e.g., acetylated LDL) and plays a role in the clearance of apoptotic cells. The protein is expressed primarily on endothelial cells and certain immune cells, contributing to vascular homeostasis and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Atherosclerosis | SCARF1 mediates uptake of modified LDL by endothelial cells, potentially contributing to foam cell formation and plaque development. | NCBI Gene, UniProt |
| Systemic Lupus Erythematosus | Defective clearance of apoptotic cells via SCARF1 may promote autoantigen exposure and autoimmune response. | OMIM, ClinVar |
| Coronary Artery Disease | Variants in SCARF1 have been associated with altered lipid metabolism and increased risk of coronary artery disease. | NCBI Gene, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Lung | 9.8 | Medium |
| Liver | 6.5 | Low |
| Spleen | 15.2 | Medium |
| Kidney | 8.1 | Low |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (endothelial) | 18.5 | High expression |
| THP-1 (monocyte) | 7.2 | Moderate expression |
| HeLa (cervical) | 3.1 | Low expression |
| A549 (lung) | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123G>A (p.Gly375Arg) | Missense | <0.01% | Unknown functional effect; reported in ClinVar |
| c.1456C>T (p.Arg486Trp) | Missense | <0.01% | Potential impact on ligand binding; limited data |
| c.1789_1791del (p.Phe597del) | In-frame deletion | <0.01% | Reported in COSMIC; functional significance unclear |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in SCARF1.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
No dominant-negative mutations identified.
View complete mutation data：
Gene Ontology (GO)
| • scavenger receptor activity | • low-density lipoprotein particle binding |
| • apoptotic cell clearance | • endocytosis |
| • cell adhesion | • immune response |
Pathways
• Scavenger receptor-mediated endocytosis
• Clearance of apoptotic cells
• Lipoprotein metabolism
Protein Summary
SCARF1 (SREC-I) is a 830-amino acid type I transmembrane protein with an N-terminal extracellular domain containing multiple scavenger receptor cysteine-rich (SRCR) repeats, a transmembrane domain, and a cytoplasmic tail. It binds and internalizes modified lipoproteins and apoptotic cells, playing a role in vascular biology and immune homeostasis. The protein is highly expressed on endothelial cells and is involved in the regulation of lipid metabolism and inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCARF1 Knockout HEK293 Cell Line | EDJ-KQ6292 | Human | 8578 | Details Get a Quote |
| SCARF1 Knockout HeLa Cell Line | EDJ-KQ54947 | Human | 8578 | Details Get a Quote |
| SCARF1 Knockout A-549 Cell Line | EDJ-KQ63432 | Human | 8578 | Details Get a Quote |
| SCARF1 Knockout HCT 116 Cell Line | EDJ-KQ71898 | Human | 8578 | Details Get a Quote |
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