SCARA5: Scavenger Receptor Class A Member 5
A ferritin receptor involved in iron homeostasis and tumor suppression
Gene Information Card
| Symbol | SCARA5 |
|---|---|
| Full Name | Scavenger Receptor Class A Member 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p21.1 |
| NCBI Gene ID | 286133 ncbi.nlm.nih.gov/gene/286133 |
| Ensembl ID | ENSG00000168079 |
| UniProt ID | Q6AZY7 |
| OMIM ID | 613730 |
| HGNC ID | 28701 |
| Aliases | NET33, TESR, Scavenger receptor class A member 5 |
Description
SCARA5 encodes a member of the scavenger receptor class A family. The protein functions as a ferritin receptor, mediating cellular uptake of iron-loaded ferritin. It is also implicated in innate immunity by binding bacterial lipopolysaccharide and in tumor suppression through regulation of cell adhesion and proliferation. SCARA5 is expressed in various tissues, with highest levels in the lung, liver, and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Loss of SCARA5 expression promotes tumor growth and metastasis via reduced ferritin uptake and altered iron metabolism. | PMID: 23934199 |
| Lung cancer | Downregulation of SCARA5 correlates with poor prognosis and increased invasive potential. | PMID: 26908329 |
| Breast cancer | SCARA5 acts as a tumor suppressor; reduced expression associated with aggressive subtypes. | PMID: 28341829 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 24.5 | High |
| Liver | 18.2 | High |
| Testis | 15.8 | High |
| Kidney | 8.3 | Medium |
| Spleen | 6.1 | Medium |
| Heart | 2.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung adenocarcinoma) | 12.1 | High expression |
| HepG2 (hepatocellular carcinoma) | 9.8 | Moderate expression |
| MCF7 (breast cancer) | 3.2 | Low expression |
| HEK293 (embryonic kidney) | 1.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349*) | Nonsense | <0.1% | Loss of function; truncation of ferritin-binding domain |
| c.782G>A (p.Arg261His) | Missense | 0.2% | Reduced ferritin binding affinity |
| c.1234_1235insA | Frameshift | <0.1% | Loss of function; premature stop codon |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg349*, c.1234_1235insA) lead to truncated or absent protein, impairing ferritin uptake and tumor suppression.
Gain of Function (GOF)
No gain-of-function mutations reported in SCARA5.
Dominant Negative (DN)
No dominant-negative mutations described for SCARA5.
View complete mutation data：
Gene Ontology (GO)
| • scavenger receptor activity (GO:0005044) | • plasma membrane (GO:0005886) |
| • ferric iron binding (GO:0008199) | • integral component of membrane (GO:0016021) |
| • iron ion transport (GO:0033572) | • response to drug (GO:0042493) |
| • innate immune response (GO:0045087) |
Pathways
• Ferritin-mediated iron uptake (Reactome: R-HSA-917937)
• Scavenger receptors in innate immunity (KEGG: hsa04610)
Protein Summary
SCARA5 is a transmembrane scavenger receptor that binds ferritin with high affinity, facilitating cellular iron uptake. It is composed of an N-terminal cytoplasmic domain, a transmembrane region, and an extracellular domain containing collagen-like and scavenger receptor cysteine-rich (SRCR) domains. The protein is involved in iron homeostasis, immune defense against bacteria, and acts as a tumor suppressor in several cancers by modulating cell adhesion and proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCARA5 Knockout HEK293 Cell Line | EDJ-KQ3142 | Human | 286133 | Details Get a Quote |
| SCARA5 Knockout A-549 Cell Line | EDJ-KQ24529 | Human | 286133 | Details Get a Quote |
| SCARA5 Knockout HeLa Cell Line | EDJ-KQ59546 | Human | 286133 | Details Get a Quote |
| SCARA5 Knockout HCT 116 Cell Line | EDJ-KQ76390 | Human | 286133 | Details Get a Quote |
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