SCARA3: Scavenger Receptor Class A Member 3
A macrophage scavenger receptor involved in oxidative stress response and potential tumor suppression
Gene Information Card
| Symbol | SCARA3 |
|---|---|
| Full Name | Scavenger Receptor Class A Member 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 8p21.1 |
| NCBI Gene ID | 5147 ncbi.nlm.nih.gov/gene/5147 |
| Ensembl ID | ENSG00000104419 |
| UniProt ID | Q6AZY7 |
| OMIM ID | 604888 |
| HGNC ID | 10600 |
| Aliases | CSR1, APC7, MSRL1, SRCL |
Description
SCARA3 (scavenger receptor class A member 3) encodes a macrophage scavenger receptor-like protein that functions in the clearance of modified low-density lipoproteins and cellular debris. It is induced by oxidative stress and may act as a tumor suppressor by protecting cells from oxidative damage. The protein is a member of the scavenger receptor family and is involved in host defense and atherosclerosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Atherosclerosis | SCARA3 mediates uptake of oxidized LDL by macrophages, contributing to foam cell formation and plaque development. | PMID: 10988299 |
| Prostate Cancer | SCARA3 expression is downregulated in prostate cancer; loss may promote tumor progression via impaired oxidative stress response. | PMID: 15126332 |
| Breast Cancer | Reduced SCARA3 expression correlates with poor prognosis; potential tumor suppressor role through ROS clearance. | PMID: 19137010 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Lung | 8.3 | Low |
| Spleen | 15.7 | Medium |
| Placenta | 20.1 | High |
| Bone Marrow | 6.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| A549 | 7.8 | Lung adenocarcinoma cell line |
| MCF7 | 5.1 | Breast cancer cell line |
| THP-1 | 18.5 | Monocytic leukemia cell line; high expression after PMA differentiation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112C>T (p.Arg38Cys) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.457G>A (p.Gly153Ser) | Missense | <0.01% | Unknown; predicted benign by in silico tools |
| c.789_790insA | Frameshift | <0.01% | Likely loss of function; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in SCARA3 are predicted to cause loss of scavenger receptor function, impairing clearance of oxidized LDL and oxidative stress response.
Gain of Function (GOF)
No gain-of-function mutations have been reported for SCARA3.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for SCARA3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Scavenger receptors in atherosclerosis (Reactome: R-HSA-3000480)
• Clearance of apoptotic cells (Reactome: R-HSA-3000481)
Protein Summary
SCARA3 is a 372-amino acid type II transmembrane glycoprotein with a collagen-like domain and a scavenger receptor cysteine-rich (SRCR) domain. It forms trimers and binds a broad range of polyanionic ligands, including oxidized LDL, bacteria, and apoptotic cells. The protein is localized to the plasma membrane and endosomes, and its expression is upregulated by oxidative stress, suggesting a protective role against cellular damage.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCARA3 Knockout HEK293 Cell Line | EDJ-KQ11093 | Human | 51435 | Details Get a Quote |
| SCARA3 Knockout A-549 Cell Line | EDJ-KQ39043 | Human | 51435 | Details Get a Quote |
| SCARA3 Knockout HCT 116 Cell Line | EDJ-KQ39044 | Human | 51435 | Details Get a Quote |
| SCARA3 Knockout HeLa Cell Line | EDJ-KQ37735 | Human | 51435 | Details Get a Quote |
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