SCAI (Suppressor of Cancer Cell Invasion)
A metastasis suppressor gene encoding a protein that inhibits cancer cell migration and invasion.
Gene Information Card
| Symbol | SCAI |
|---|---|
| Full Name | Suppressor of Cancer Cell Invasion |
| Gene Type | Protein coding |
| Chromosomal Location | 9q22.33 |
| NCBI Gene ID | 286205 ncbi.nlm.nih.gov/gene/286205 |
| Ensembl ID | ENSG00000165029 |
| UniProt ID | Q8N5M9 |
| OMIM ID | 614144 |
| HGNC ID | 26956 |
| Aliases | DKFZp686O24166, FLJ38973, MGC138290 |
Description
SCAI (Suppressor of Cancer Cell Invasion) is a protein-coding gene located on chromosome 9q22.33. The encoded protein functions as a metastasis suppressor by inhibiting cancer cell migration and invasion, likely through regulation of cytoskeletal dynamics and cell adhesion. SCAI is downregulated in various cancers, and its loss correlates with increased metastatic potential.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Loss of SCAI expression promotes invasion and metastasis | PMID: 23431173 |
| Colorectal cancer | SCAI downregulation associated with poor prognosis and metastasis | PMID: 25944712 |
| Lung cancer | Reduced SCAI expression correlates with increased cell migration | PMID: 27562874 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 6.2 | Low |
| Breast | 4.8 | Low |
| Colon | 3.5 | Low |
| Prostate | 5.1 | Low |
| Ovary | 4.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 2.1 | Low expression; invasive phenotype |
| HCT116 (colorectal cancer) | 1.8 | Low expression; metastatic potential |
| A549 (lung cancer) | 3.0 | Moderate expression; reduced invasion upon SCAI overexpression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; likely loss of function |
| c.325C>T (p.Arg109Trp) | Missense | <0.01% | Unknown functional effect; rare variant |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations (e.g., start codon loss) are predicted to reduce SCAI protein levels, leading to increased cancer cell invasion.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • actin binding (GO:0003779) | • cytoskeleton (GO:0005856) |
| • cell migration (GO:0016477) | • negative regulation of cell migration (GO:0030336) |
| • positive regulation of GTPase activity (GO:0043547) |
Pathways
• Regulation of actin cytoskeleton (Reactome: R-HSA-5663205)
• Signaling by Rho GTPases (Reactome: R-HSA-194315)
Protein Summary
The SCAI protein (UniProt Q8N5M9) is a 729-amino acid protein that localizes to the cytoplasm and cytoskeleton. It contains an actin-binding domain and interacts with Rho GTPases to negatively regulate cell migration and invasion. SCAI acts as a metastasis suppressor by modulating cytoskeletal reorganization and cell adhesion dynamics.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SCAI Knockout HEK293 Cell Line | EDJ-KQ15181 | Human | 286205 | Details Get a Quote |
| SCAI Knockout A-549 Cell Line | EDJ-KQ47966 | Human | 286205 | Details Get a Quote |
| SCAI Knockout HCT 116 Cell Line | EDJ-KQ47967 | Human | 286205 | Details Get a Quote |
| SCAI Knockout HeLa Cell Line | EDJ-KQ47968 | Human | 286205 | Details Get a Quote |
