S1PR4 (Sphingosine-1-Phosphate Receptor 4)
A G protein-coupled receptor involved in immune regulation and lymphocyte trafficking.
Gene Information Card
| Symbol | S1PR4 |
|---|---|
| Full Name | sphingosine-1-phosphate receptor 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 8698 ncbi.nlm.nih.gov/gene/8698 |
| Ensembl ID | ENSG00000125968 |
| UniProt ID | O95977 |
| OMIM ID | 603751 |
| HGNC ID | 10965 |
| Aliases | EDG6, LPC1, S1P4 |
Description
S1PR4 (sphingosine-1-phosphate receptor 4) is a member of the endothelial differentiation gene (EDG) family of G protein-coupled receptors. It binds the bioactive lipid sphingosine-1-phosphate (S1P) and is primarily expressed in lymphoid and hematopoietic tissues. S1PR4 plays a role in immune cell migration, cytokine production, and vascular development. It is involved in lymphocyte trafficking and has been implicated in immune disorders and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Immunodeficiency | Altered S1P signaling affecting lymphocyte egress from lymphoid organs | PMID: 12867038 |
| Multiple sclerosis | Modulation of S1P receptor activity influences neuroinflammation | PMID: 20428110 |
| Cancer (e.g., leukemia) | Aberrant S1PR4 expression may promote tumor cell survival and migration | PMID: 21502568 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Thymus | 7.9 | Low |
| Peripheral blood leukocytes | 15.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 14.2 | High expression |
| Raji (Burkitt lymphoma) | 11.5 | Medium expression |
| K562 (chronic myeloid leukemia) | 6.8 | Low expression |
| HEK293 (embryonic kidney) | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
| c.421G>A (p.Gly141Ser) | Missense | <0.01% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
p.Gly141Ser may impair receptor signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • sphingosine-1-phosphate receptor activity |
| • cell surface receptor signaling pathway | • lymphocyte chemotaxis |
| • positive regulation of cell migration |
Pathways
• Sphingosine-1-phosphate (S1P) signaling
• G alpha (i) signaling events
• Lymphocyte trafficking
Protein Summary
S1PR4 is a 384-amino acid integral membrane protein with seven transmembrane domains. It couples primarily to Gi/o proteins, leading to inhibition of adenylyl cyclase and activation of MAPK and PI3K pathways. The receptor is critical for S1P-mediated lymphocyte egress from lymphoid organs and modulates immune responses. Its expression is largely restricted to hematopoietic cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S1PR4 Knockout HEK293 Cell Line | EDJ-KQ50817 | Human | 8698 | Details Get a Quote |
| S1PR4 Knockout HeLa Cell Line | EDJ-KQ54983 | Human | 8698 | Details Get a Quote |
| S1PR4 Knockout A-549 Cell Line | EDJ-KQ63465 | Human | 8698 | Details Get a Quote |
| S1PR4 Knockout HCT 116 Cell Line | EDJ-KQ71933 | Human | 8698 | Details Get a Quote |
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