S100PBP
S100P Binding Protein
Gene Information Card
| Symbol | S100PBP |
|---|---|
| Full Name | S100P binding protein |
| Gene Type | protein-coding |
| Chromosomal Location | 1p35.3 |
| NCBI Gene ID | 64766 ncbi.nlm.nih.gov/gene/64766 |
| Ensembl ID | ENSG00000143149 |
| UniProt ID | Q96BU1 |
| OMIM ID | 617808 |
| HGNC ID | 24482 |
| Aliases | S100PBP, FLJ11273, MGC138290 |
Description
S100PBP (S100P binding protein) is a protein-coding gene located on chromosome 1p35.3. The encoded protein binds to S100P, a member of the S100 family of calcium-binding proteins, and may modulate S100P-mediated signaling. S100PBP is expressed in multiple tissues and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | S100PBP may influence S100P-driven tumor progression; altered expression reported in various cancers. | COSMIC; literature |
| Breast cancer | S100PBP expression changes observed; potential role in metastasis via S100P interaction. | COSMIC; literature |
| Pancreatic cancer | S100PBP overexpression linked to S100P signaling and poor prognosis. | COSMIC; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.3 | Low |
| Liver | 4.1 | Low |
| Kidney | 5.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Moderate expression |
| HeLa | 8.5 | Low expression |
| MCF7 | 6.2 | Low expression |
| A549 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.100C>T | synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • calcium-dependent protein binding |
| • cytoplasm | • nucleus |
Pathways
• S100P signaling pathway
Protein Summary
The S100PBP protein is a 408-amino acid polypeptide that binds specifically to S100P. It is localized in the cytoplasm and nucleus, and may regulate S100P-mediated cellular processes such as proliferation, migration, and invasion. Its exact molecular function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S100PBP Knockout HEK293 Cell Line | EDJ-KQ15155 | Human | 64766 | Details Get a Quote |
| S100PBP Knockout HCT 116 Cell Line | EDJ-KQ44526 | Human | 64766 | Details Get a Quote |
| S100PBP Knockout A-549 Cell Line | EDJ-KQ45756 | Human | 64766 | Details Get a Quote |
| S100PBP Knockout HeLa Cell Line | EDJ-KQ45757 | Human | 64766 | Details Get a Quote |
