S100P: A Calcium-Binding Protein with Roles in Cancer and Inflammation

Comprehensive genomic and proteomic overview of S100P, a member of the S100 family of EF-hand calcium-binding proteins, implicated in tumorigenesis, metastasis, and inflammatory responses.

Gene Information Card

Symbol S100P
Full Name S100 calcium binding protein P
Gene Type protein-coding
Chromosomal Location 4p16.1
NCBI Gene ID 6286 ncbi.nlm.nih.gov/gene/6286
Ensembl ID ENSG00000163993
UniProt ID P25815
OMIM ID 600614
HGNC ID 10503
Aliases S100P, MIG9, S100 calcium-binding protein P

Description

S100P is a member of the S100 family of EF-hand calcium-binding proteins. It is involved in calcium-dependent signal transduction, cell cycle progression, differentiation, and cytoskeletal dynamics. Overexpression of S100P is associated with various cancers, including pancreatic, breast, lung, and colorectal cancers, where it promotes tumor growth, invasion, and metastasis. S100P also plays roles in inflammation and immune modulation.

Disease Associations

Disease category Pathophysiological mechanism Genomic evidence
Pancreatic ductal adenocarcinoma Overexpression of S100P enhances cell proliferation and invasion via RAGE and NF-κB signaling PMID: 19029981; COSMIC
Breast cancer S100P upregulation correlates with poor prognosis and metastasis through interaction with ezrin and activation of MAPK pathway PMID: 21573172; COSMIC
Colorectal cancer S100P promotes tumor growth and chemoresistance via calcium-dependent signaling and interaction with S100A4 PMID: 23034449; COSMIC
Non-small cell lung cancer Elevated S100P expression associated with lymph node metastasis and shorter survival PMID: 23403476; COSMIC
Inflammatory bowel disease S100P expression increased in inflamed colonic mucosa, potentially contributing to chronic inflammation PMID: 19637289

Expression Profile

Tissue Expression
Tissue nTPM level
Pancreas 112.3 High
Breast 45.6 Medium
Lung 38.2 Medium
Colon 29.8 Medium
Stomach 22.1 Low
Liver 8.4 Low
Kidney 5.2 Low
Cell Line Expression
Cell Line nTPM Notes
PANC-1 (pancreatic cancer) 156.7 Overexpressed
MCF-7 (breast cancer) 89.4 Moderate expression
A549 (lung cancer) 72.3 Moderate expression
HT-29 (colorectal cancer) 63.1 Moderate expression
HEK293 (embryonic kidney) 12.5 Low expression
Data source：Human Protein Atlas（proteinatlas.org）

Mutations & Variants

Hotspot Mutations
Variant Type Frequency Functional Description
c.68C>T (p.Pro23Leu) Missense 0.2% in COSMIC Unknown functional impact
c.101G>A (p.Arg34His) Missense 0.1% in COSMIC Unknown functional impact
c.154G>A (p.Glu52Lys) Missense 0.05% in COSMIC Unknown functional impact
Mutation functional classification

Loss of Function (LOF)

No confirmed loss-of-function mutations reported in S100P.

Gain of Function (GOF)

Overexpression and amplification are common in cancers, suggesting gain-of-function effects.

Dominant Negative (DN)

No dominant-negative mutations described for S100P.
View complete mutation data：
ClinVar：https://www.clinvar.com/gene/6286
COSMIC：https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=S100P

Gene Ontology (GO)

• calcium ion binding (GO:0005509) • protein binding (GO:0005515)
• cytoplasm (GO:0005737) • plasma membrane (GO:0005886)
• signal transduction (GO:0007165) • cell proliferation (GO:0008283)
• membrane (GO:0016020) • negative regulation of apoptotic process (GO:0043066)
• extracellular matrix binding (GO:0050840)

Pathways

• RAGE signaling pathway (Reactome: R-HSA-194315)
• NF-κB signaling pathway (KEGG: hsa04064)
• MAPK signaling pathway (KEGG: hsa04010)
• Calcium signaling pathway (KEGG: hsa04020)

Protein Summary

S100P is a 95-amino acid protein (molecular weight ~10.4 kDa) belonging to the S100 family. It contains two EF-hand calcium-binding motifs and undergoes calcium-dependent conformational changes that expose hydrophobic surfaces for interaction with target proteins such as ezrin, RAGE, and S100A4. S100P is predominantly cytosolic but can be secreted or translocated to the membrane. It regulates cell proliferation, motility, invasion, and survival, and is considered a potential biomarker and therapeutic target in several cancers.

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Related Products

Product name Cat.No. Species Gene ID
S100P Knockout HEK293 Cell Line EDJ-KQ4955 Human 6286 Details Get a Quote
S100PBP Knockout HEK293 Cell Line EDJ-KQ15155 Human 64766 Details Get a Quote
S100P Knockout A-549 Cell Line EDJ-KQ29081 Human 6286 Details Get a Quote
S100P Knockout HCT 116 Cell Line EDJ-KQ29083 Human 6286 Details Get a Quote
S100P Knockout HeLa Cell Line EDJ-KQ29084 Human 6286 Details Get a Quote
S100PBP Knockout HCT 116 Cell Line EDJ-KQ44526 Human 64766 Details Get a Quote
S100PBP Knockout A-549 Cell Line EDJ-KQ45756 Human 64766 Details Get a Quote
S100PBP Knockout HeLa Cell Line EDJ-KQ45757 Human 64766 Details Get a Quote

Reference Databases

NCBI Gene https://www.ncbi.nlm.nih.gov/gene/6286
OMIM https://www.omim.org/entry/600614
HGNC https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10503
Ensembl https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163993
UniProt https://www.uniprot.org/uniprot/P25815
ClinVar https://www.ncbi.nlm.nih.gov/clinvar/?term=S100P%5Bgene%5D
COSMIC https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=S100P
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