S100A7A Gene - S100 Calcium Binding Protein A7A
Comprehensive genomic and proteomic analysis of S100A7A, a member of the S100 family involved in inflammation and cancer.
Gene Information Card
| Symbol | S100A7A |
|---|---|
| Full Name | S100 calcium binding protein A7A |
| Gene Type | protein-coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 338324 ncbi.nlm.nih.gov/gene/338324 |
| Ensembl ID | ENSG00000184349 |
| UniProt ID | Q86SG5 |
| OMIM ID | 618583 |
| HGNC ID | 32399 |
| Aliases | S100A15, S100A7L1 |
Description
S100A7A (S100 calcium binding protein A7A) is a member of the S100 family of EF-hand calcium-binding proteins. It is located in the epidermal differentiation complex on chromosome 1q21.3. S100A7A is involved in innate immune responses, inflammation, and keratinocyte differentiation. It is upregulated in psoriatic skin and certain cancers, including breast and lung cancer, where it may promote tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Psoriasis | Overexpression in psoriatic epidermis; promotes inflammation via chemotaxis and cytokine induction | PubMed, NCBI Gene |
| Breast cancer | Upregulated in invasive breast carcinoma; associated with poor prognosis | PubMed, COSMIC |
| Lung cancer | Elevated expression in non-small cell lung cancer; linked to metastasis | PubMed, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Esophagus | 8.3 | Low |
| Breast | 5.1 | Low |
| Lung | 3.2 | Low |
| Tongue | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocyte) | 15.2 | High expression |
| MCF-7 (breast cancer) | 7.8 | Moderate expression |
| A549 (lung cancer) | 4.5 | Low expression |
| HEK293 (embryonic kidney) | 1.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.152G>A (p.Arg51Gln) | Missense | <0.01% | Unknown functional effect |
| c.206C>T (p.Thr69Ile) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in S100A7A.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in S100A7A.
Dominant Negative (DN)
No dominant-negative mutations reported in S100A7A.
View complete mutation data：
Gene Ontology (GO)
Pathways
• S100 family signaling pathway
• Innate immune system
• RAGE receptor binding
Protein Summary
S100A7A is a 101-amino acid protein (11.4 kDa) containing two EF-hand calcium-binding domains. It functions as a homodimer and can also heterodimerize with S100A7. The protein is secreted and acts as a chemoattractant for immune cells, particularly neutrophils and T cells. It binds to the receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4), activating NF-κB and MAPK signaling pathways. S100A7A is implicated in antimicrobial defense, wound healing, and tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S100A7A Knockout HEK293 Cell Line | EDJ-KQ15153 | Human | 338324 | Details Get a Quote |
| S100A7A Knockout HeLa Cell Line | EDJ-KQ59606 | Human | 338324 | Details Get a Quote |
| S100A7A Knockout A-549 Cell Line | EDJ-KQ68071 | Human | 338324 | Details Get a Quote |
| S100A7A Knockout HCT 116 Cell Line | EDJ-KQ76448 | Human | 338324 | Details Get a Quote |
