S100A16
S100 Calcium Binding Protein A16
Gene Information Card
| Symbol | S100A16 |
|---|---|
| Full Name | S100 calcium binding protein A16 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 140576 ncbi.nlm.nih.gov/gene/140576 |
| Ensembl ID | ENSG00000163191 |
| UniProt ID | Q96FQ6 |
| OMIM ID | 618597 |
| HGNC ID | 20441 |
| Aliases | S100F, AAG13 |
Description
S100A16 is a member of the S100 family of calcium-binding proteins. It is involved in calcium signaling, cell cycle regulation, and differentiation. Overexpression is associated with tumor progression and metastasis in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes proliferation and invasion via calcium-dependent pathways | PMID: 25605247 |
| Colorectal cancer | Upregulation correlates with poor prognosis and metastasis | PMID: 27121310 |
| Gastric cancer | High expression linked to lymph node metastasis and reduced survival | PMID: 28692054 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 10.1 | Medium |
| Lung | 6.7 | Low |
| Stomach | 9.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HCT116 (colorectal cancer) | 13.8 | High expression |
| A549 (lung cancer) | 7.1 | Low expression |
| HEK293 (embryonic kidney) | 5.6 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.157C>T (p.Arg53Cys) | Missense | <0.1% (COSMIC) | Unknown functional impact |
| c.208G>A (p.Glu70Lys) | Missense | <0.1% (COSMIC) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function in oncogenesis.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding | • protein homodimerization activity |
| • regulation of cell cycle | • positive regulation of cell migration |
Pathways
• S100 protein signaling
• Calcium signaling pathway
Protein Summary
S100A16 is a 103-amino acid calcium-binding protein (UniProt Q96FQ6) that forms homodimers. It modulates calcium-dependent cellular processes including proliferation, migration, and differentiation. Elevated in multiple cancers, it is considered a potential biomarker and therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S100A16 Knockout HEK293 Cell Line | EDJ-KQ9784 | Human | 140576 | Details Get a Quote |
| S100A16 Knockout HeLa Cell Line | EDJ-KQ35422 | Human | 140576 | Details Get a Quote |
| S100A16 Knockout A-549 Cell Line | EDJ-KQ36632 | Human | 140576 | Details Get a Quote |
| S100A16 Knockout HCT 116 Cell Line | EDJ-KQ36633 | Human | 140576 | Details Get a Quote |
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