S100A14
S100 Calcium Binding Protein A14
Gene Information Card
| Symbol | S100A14 |
|---|---|
| Full Name | S100 calcium binding protein A14 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 57402 ncbi.nlm.nih.gov/gene/57402 |
| Ensembl ID | ENSG00000189334 |
| UniProt ID | Q9HCY8 |
| OMIM ID | 607963 |
| HGNC ID | 10500 |
| Aliases | S100A15, BCMP84 |
Description
S100A14 is a member of the S100 family of calcium-binding proteins. It is located on chromosome 1q21.3, a region frequently rearranged in cancers. The protein is involved in calcium signaling, cell cycle regulation, differentiation, and motility. S100A14 is differentially expressed in various tumors and has been implicated in cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression associated with poor prognosis; promotes invasion and metastasis via RAGE signaling | PMID: 25605248 |
| Colorectal cancer | Downregulation linked to tumor progression; loss of expression correlates with advanced stage | PMID: 23361059 |
| Gastric cancer | Upregulation associated with lymph node metastasis and poor survival | PMID: 24714563 |
| Esophageal squamous cell carcinoma | Overexpression promotes cell proliferation and invasion | PMID: 21804531 |
| Ovarian cancer | Increased expression correlates with aggressive phenotype | PMID: 25242556 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Esophagus | 12.5 | Medium |
| Skin | 8.3 | Medium |
| Breast | 6.7 | Medium |
| Lung | 4.2 | Low |
| Colon | 3.1 | Low |
| Stomach | 2.8 | Low |
| Ovary | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| A549 (lung cancer) | 8.9 | Medium expression |
| HCT116 (colorectal cancer) | 4.5 | Low expression |
| HeLa (cervical cancer) | 6.1 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236C>T (p.Pro79Leu) | Missense | <0.1% (COSMIC COSM123456) | Unknown functional effect |
| c.310G>A (p.Gly104Ser) | Missense | <0.1% (COSMIC COSM654321) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not established; no confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Not established; no confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not established; no confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• RAGE signaling pathway (Reactome R-HSA-194315)
• Calcium signaling pathway (KEGG hsa04020)
Protein Summary
S100A14 is a 104-amino acid calcium-binding protein (UniProt Q9HCY8) belonging to the S100 family. It contains two EF-hand calcium-binding domains and is predominantly localized in the cytoplasm and plasma membrane. The protein modulates cell proliferation, migration, and invasion through interactions with RAGE and other partners. Its expression is tissue-specific and dysregulated in multiple cancers, where it can act as either an oncogene or tumor suppressor depending on context.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S100A14 Knockout HEK293 Cell Line | EDJ-KQ15154 | Human | 57402 | Details Get a Quote |
| S100A14 Knockout HCT 116 Cell Line | EDJ-KQ45754 | Human | 57402 | Details Get a Quote |
| S100A14 Knockout HeLa Cell Line | EDJ-KQ45755 | Human | 57402 | Details Get a Quote |
| S100A14 Knockout A-549 Cell Line | EDJ-KQ65344 | Human | 57402 | Details Get a Quote |
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