S100A11 (S100 Calcium Binding Protein A11)
A multifunctional calcium-binding protein involved in cell cycle regulation, differentiation, and cancer progression.
Gene Information Card
| Symbol | S100A11 |
|---|---|
| Full Name | S100 calcium binding protein A11 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 6282 ncbi.nlm.nih.gov/gene/6282 |
| Ensembl ID | ENSG00000163191 |
| UniProt ID | P31949 |
| OMIM ID | 603114 |
| HGNC ID | 10490 |
| Aliases | S100C, calgizzarin, MLN70 |
Description
S100A11 is a member of the S100 family of calcium-binding proteins. It is involved in calcium-dependent signaling, regulating cell cycle progression, differentiation, and cytoskeletal dynamics. The protein is overexpressed in various cancers and has been implicated in tumor growth and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and invasion via NF-κB and MAPK pathways | PMID: 25645623 |
| Colorectal cancer | Upregulation correlates with poor prognosis and metastasis | PMID: 27126917 |
| Gastric cancer | High expression linked to tumor stage and lymph node metastasis | PMID: 28407145 |
| Prostate cancer | S100A11 enhances androgen receptor signaling and cell survival | PMID: 29351288 |
| Psoriasis | Increased expression in keratinocytes contributes to inflammation | PMID: 12634856 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 10.1 | Medium |
| Prostate | 7.6 | Low |
| Lung | 9.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HCT116 (colorectal cancer) | 13.8 | High expression |
| A549 (lung cancer) | 11.5 | Medium expression |
| HaCaT (keratinocyte) | 14.0 | High expression |
| PC3 (prostate cancer) | 9.8 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Glu32Lys) | Missense | <0.1% | Unknown functional impact |
| c.205C>T (p.Arg69Trp) | Missense | <0.1% | Reported in COSMIC; potential loss of calcium binding |
| c.277G>A (p.Gly93Arg) | Missense | <0.1% | Observed in cancer samples; significance unclear |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Overexpression and amplification are common in cancers, suggesting gain-of-function effects.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding | • protein homodimerization activity |
| • cell cycle | • cell differentiation |
| • positive regulation of cell proliferation | • negative regulation of apoptosis |
| • cytoskeleton organization |
Pathways
• RAGE signaling pathway
• NF-κB signaling pathway
• MAPK signaling pathway
• p53 signaling pathway
Protein Summary
S100A11 is a 105-amino acid calcium-binding protein (11 kDa) that exists as a homodimer. Upon calcium binding, it undergoes a conformational change that allows interaction with target proteins such as annexin A1, p53, and transglutaminase. It is involved in cell cycle regulation, differentiation, and inflammation. Overexpression is observed in multiple cancers and is associated with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| S100A11 Knockout HEK293 Cell Line | EDJ-KQ50602 | Human | 6282 | Details Get a Quote |
| S100A11 Knockout HeLa Cell Line | EDJ-KQ54380 | Human | 6282 | Details Get a Quote |
| S100A11 Knockout A-549 Cell Line | EDJ-KQ62873 | Human | 6282 | Details Get a Quote |
| S100A11 Knockout HCT 116 Cell Line | EDJ-KQ71339 | Human | 6282 | Details Get a Quote |
