RUSF1 (RUS Family Member 1)
A poorly characterized gene with potential roles in cellular processes; limited clinical significance.
Gene Information Card
| Symbol | RUSF1 |
|---|---|
| Full Name | RUS family member 1 |
| Gene Type | protein coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 113177 ncbi.nlm.nih.gov/gene/113177 |
| Ensembl ID | ENSG00000161944 |
| UniProt ID | Q5T1J5 |
| OMIM ID | Not available |
| HGNC ID | HGNC:28759 |
| Aliases | FLJ32658, MGC26717 |
Description
RUSF1 is a protein-coding gene located on chromosome 16p13.3. The gene encodes a protein of unknown function, but it is predicted to be involved in cellular processes based on sequence similarity. Expression data suggest ubiquitous low-level expression. No specific disease associations have been firmly established.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated disease links in OMIM or ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Kidney | 4.1 | Low |
| Liver | 3.8 | Low |
| Brain | 3.5 | Low |
| Lung | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 4.5 | Low expression |
| A549 | 3.9 | Low expression |
| MCF7 | 3.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No significant mutations reported | Not applicable | Not applicable | No known pathogenic variants |
Mutation functional classification
Loss of Function (LOF)
No evidence for loss-of-function mutations.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: Not characterized | • Biological process: Not characterized |
| • Cellular component: Not characterized |
Pathways
• No known pathways
Protein Summary
The RUSF1 protein is predicted to be a small, soluble protein with no known functional domains. Its function remains largely unknown, and it is not associated with any major biological pathway or disease.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RUSF1 Knockout HEK293 Cell Line | EDJ-KQ15151 | Human | 64755 | Details Get a Quote |
| RUSF1 Knockout A-549 Cell Line | EDJ-KQ45748 | Human | 64755 | Details Get a Quote |
| RUSF1 Knockout HCT 116 Cell Line | EDJ-KQ45749 | Human | 64755 | Details Get a Quote |
| RUSF1 Knockout HeLa Cell Line | EDJ-KQ45750 | Human | 64755 | Details Get a Quote |
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