RSL24D1 Gene - Ribosomal L24 Domain Containing 1
A comprehensive biomedical overview of RSL24D1, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | RSL24D1 |
|---|---|
| Full Name | Ribosomal L24 Domain Containing 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q22.31 |
| NCBI Gene ID | 51187 ncbi.nlm.nih.gov/gene/51187 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | Q9Y3Q8 |
| OMIM ID | Not available |
| HGNC ID | 18757 |
| Aliases | C15orf15, L24, RPL24, RPL24P1 |
Description
RSL24D1 encodes a protein containing a ribosomal L24 domain, suggesting a role in ribosome biogenesis or translation. The gene is located on chromosome 15q22.31 and is broadly expressed in human tissues. Alterations in RSL24D1 have been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of ribosome biogenesis; overexpression observed in multiple tumor types | COSMIC; literature |
| Colorectal cancer | Upregulation of RSL24D1 associated with poor prognosis | COSMIC; literature |
| Breast cancer | Altered expression linked to tumor progression | COSMIC; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 11.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | High expression |
| HeLa | 14.2 | Medium expression |
| K562 | 12.0 | Medium expression |
| MCF7 | 10.3 | Medium expression |
| A549 | 9.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; uncertain significance |
| c.202C>T (p.Arg68Trp) | Missense | <0.01% | Unknown significance |
| c.415G>A (p.Gly139Ser) | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • structural constituent of ribosome (GO:0003735) | • translation (GO:0006412) |
| • cytosolic large ribosomal subunit (GO:0022625) | • cytoplasm (GO:0005737) |
Pathways
• Ribosome (KEGG hsa03010)
• Eukaryotic translation initiation (Reactome R-HSA-72649)
Protein Summary
RSL24D1 is a 164-amino acid protein containing a ribosomal L24 domain. It is predicted to localize to the cytoplasm and be part of the large ribosomal subunit, consistent with a role in protein synthesis. The protein is broadly expressed, with highest levels in testis and lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RSL24D1 Knockout HEK293 Cell Line | EDJ-KQ51290 | Human | 51187 | Details Get a Quote |
| RSL24D1 Knockout HeLa Cell Line | EDJ-KQ56246 | Human | 51187 | Details Get a Quote |
| RSL24D1 Knockout A-549 Cell Line | EDJ-KQ64735 | Human | 51187 | Details Get a Quote |
| RSL24D1 Knockout HCT 116 Cell Line | EDJ-KQ73180 | Human | 51187 | Details Get a Quote |
