RPS4Y2
Ribosomal Protein S4 Y-Linked 2
Gene Information Card
| Symbol | RPS4Y2 |
|---|---|
| Full Name | Ribosomal Protein S4 Y-Linked 2 |
| Gene Type | protein-coding |
| Chromosomal Location | Yq11.223 |
| NCBI Gene ID | 140032 ncbi.nlm.nih.gov/gene/140032 |
| Ensembl ID | ENSG00000183878 |
| UniProt ID | P22090 |
| OMIM ID | 400028 |
| HGNC ID | 10426 |
| Aliases | RPS4Y2P, RPS4Y2_1 |
Description
RPS4Y2 (Ribosomal Protein S4 Y-Linked 2) is a protein-coding gene located on the Y chromosome. It encodes a component of the small 40S ribosomal subunit, playing a role in protein synthesis. This gene is expressed predominantly in male tissues and is part of the ribosomal protein family.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific diseases curated | Not applicable | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Prostate | 5.1 | Low |
| Salivary gland | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.5 | Very low |
| K562 | 0.3 | Very low |
| HEK293 | 0.4 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • structural constituent of ribosome (GO:0003735) | • translation (GO:0006412) |
| • cytosolic small ribosomal subunit (GO:0022627) |
Pathways
• Ribosome (KEGG hsa03010)
Protein Summary
RPS4Y2 encodes a ribosomal protein that is a component of the 40S small ribosomal subunit. It is highly similar to the X-linked RPS4X protein and is expressed in a male-specific manner. The protein is involved in mRNA translation and ribosome assembly.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RPS4Y2 Knockout HEK293 Cell Line | EDJ-KQ9675 | Human | 140032 | Details Get a Quote |
| RPS4Y2 Knockout HeLa Cell Line | EDJ-KQ58426 | Human | 140032 | Details Get a Quote |
| RPS4Y2 Knockout A-549 Cell Line | EDJ-KQ66915 | Human | 140032 | Details Get a Quote |
| RPS4Y2 Knockout HCT 116 Cell Line | EDJ-KQ75319 | Human | 140032 | Details Get a Quote |
