RPLP2 (Ribosomal Protein Lateral Stalk Subunit P2)
A core component of the ribosomal 60S large subunit, essential for translational elongation and implicated in cancer and autoimmune disorders.
Gene Information Card
| Symbol | RPLP2 |
|---|---|
| Full Name | Ribosomal Protein Lateral Stalk Subunit P2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 6181 ncbi.nlm.nih.gov/gene/6181 |
| Ensembl ID | ENSG00000177600 |
| UniProt ID | P05387 |
| OMIM ID | 180470 |
| HGNC ID | 10377 |
| Aliases | LP2, P2, RPP2, D11S2243E |
Description
RPLP2 encodes the ribosomal protein P2, a component of the 60S large ribosomal subunit. The protein forms part of the lateral stalk structure that binds elongation factors and is critical for efficient mRNA translation. RPLP2 is highly conserved and expressed in all eukaryotic cells. Its expression is dysregulated in several cancers and it is a known autoantigen in systemic lupus erythematosus.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus | Autoantibodies against ribosomal P proteins (including RPLP2) target the ribosome, contributing to immune complex formation and tissue damage. | OMIM 180470; ClinVar |
| Colorectal cancer | Overexpression of RPLP2 promotes protein synthesis and cell proliferation. | COSMIC; PubMed studies |
| Hepatocellular carcinoma | Upregulation of RPLP2 correlates with poor prognosis and increased metastatic potential. | COSMIC; PubMed studies |
| Breast cancer | RPLP2 is overexpressed in tumor tissues and associated with aggressive subtypes. | COSMIC; PubMed studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Brain | 8.3 | Low |
| Colon | 15.2 | Medium |
| Heart | 6.1 | Low |
| Kidney | 10.4 | Medium |
| Liver | 14.8 | Medium |
| Lung | 11.2 | Medium |
| Pancreas | 9.7 | Low |
| Prostate | 13.1 | Medium |
| Spleen | 7.5 | Low |
| Testis | 18.6 | High |
| Thyroid | 10.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.3 | Cervical carcinoma cell line; high expression |
| HEK293 | 19.7 | Embryonic kidney cells; high expression |
| K562 | 15.4 | Leukemia cell line; medium expression |
| MCF7 | 17.8 | Breast cancer cell line; high expression |
| HepG2 | 20.1 | Hepatocellular carcinoma cell line; high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Glu32Lys) | Missense | <0.1% | Reported in COSMIC; functional impact unknown |
| c.148C>T (p.Arg50Cys) | Missense | <0.1% | Reported in COSMIC; potential loss of function |
| c.205_207del (p.Lys69del) | In-frame deletion | <0.1% | Reported in COSMIC; may affect protein stability |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations in RPLP2 have been reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations in RPLP2 have been reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations in RPLP2 have been reported.
View complete mutation data：
Gene Ontology (GO)
| • structural constituent of ribosome (GO:0003735) | • translation (GO:0006412) |
| • cytoplasmic translation (GO:0002181) | • cytosolic large ribosomal subunit (GO:0022625) |
| • ribosome (GO:0005840) |
Pathways
• KEGG hsa03010: Ribosome
• Reactome R-HSA-156902: Peptide chain elongation
• Reactome R-HSA-72766: Translation
Protein Summary
RPLP2 is a 115-amino-acid acidic ribosomal protein (11.7 kDa) that forms a homodimer with RPLP1 and associates with RPLP0 to create the ribosomal stalk. This stalk is essential for recruiting elongation factors eEF1A and eEF2 during translation. The protein contains a conserved C-terminal domain that is highly acidic and mediates interactions with the ribosome. Post-translational modifications include phosphorylation at Ser105, which regulates ribosome binding. RPLP2 is also a major autoantigen in systemic lupus erythematosus, where anti-P antibodies target the C-terminal region.
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