RPL39L
Ribosomal Protein L39 Like
Gene Information Card
| Symbol | RPL39L |
|---|---|
| Full Name | Ribosomal Protein L39 Like |
| Gene Type | protein-coding |
| Chromosomal Location | 3q27.3 |
| NCBI Gene ID | 116517 ncbi.nlm.nih.gov/gene/116517 |
| Ensembl ID | ENSG00000163923 |
| UniProt ID | Q96EH5 |
| OMIM ID | 617951 |
| HGNC ID | 16628 |
| Aliases | L39-2, RPL39_2_1041 |
Description
RPL39L encodes a ribosomal protein that is a component of the 60S ribosomal subunit. This gene is a paralog of RPL39 and is involved in ribosome biogenesis and protein synthesis. RPL39L expression is enriched in testis and certain cancers, suggesting a role in specialized translation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Overexpression of RPL39L in tumors may alter ribosome composition and promote translation of oncogenic mRNAs. | COSMIC; PMID: 25691885 |
| Male infertility | Reduced RPL39L expression in testis may impair spermatogenesis. | UniProt; PMID: 22922874 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 38.2 | High |
| Brain | 1.5 | Low |
| Liver | 0.8 | Not detected |
| Heart | 0.6 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.3 | Moderate expression |
| HeLa | 8.7 | Moderate expression |
| K562 | 2.1 | Low expression |
| MCF7 | 15.4 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94C>T (p.Arg32Cys) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.148G>A (p.Gly50Ser) | Missense | 0.005% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • structural constituent of ribosome | • ribosome biogenesis |
| • translation | • cytoplasmic translation |
| • ribosomal large subunit assembly |
Pathways
• Eukaryotic Translation Elongation
• Ribosome (KEGG hsa03010)
Protein Summary
RPL39L is a 51-amino acid protein that belongs to the L39E family of ribosomal proteins. It localizes to the large ribosomal subunit and is thought to play a role in translational regulation. The protein shares high sequence similarity with RPL39 but shows tissue-specific expression, particularly in testis and certain cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RPL39L Knockout HEK293 Cell Line | EDJ-KQ6917 | Human | 116832 | Details Get a Quote |
| RPL39L Knockout A-549 Cell Line | EDJ-KQ32896 | Human | 116832 | Details Get a Quote |
| RPL39L Knockout HeLa Cell Line | EDJ-KQ32898 | Human | 116832 | Details Get a Quote |
| RPL39L Knockout HCT 116 Cell Line | EDJ-KQ74907 | Human | 116832 | Details Get a Quote |
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