RNF7 (Ring Finger Protein 7)
A component of the SCF ubiquitin ligase complex involved in cell cycle regulation and apoptosis
Gene Information Card
| Symbol | RNF7 |
|---|---|
| Full Name | Ring Finger Protein 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q22.3 |
| NCBI Gene ID | 9616 ncbi.nlm.nih.gov/gene/9616 |
| Ensembl ID | ENSG00000114127 |
| UniProt ID | Q9UBV8 |
| OMIM ID | 603863 |
| HGNC ID | 10071 |
| Aliases | SAG, ROC2, Rbx2, H-REV107-1 |
Description
RNF7 (Ring Finger Protein 7), also known as SAG (Sensitive to Apoptosis Gene), encodes a protein that functions as a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. It contains a RING finger domain and is involved in ubiquitination and subsequent proteasomal degradation of target proteins, playing roles in cell cycle progression, apoptosis, and response to oxidative stress.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | RNF7 overexpression promotes cell proliferation and inhibits apoptosis through enhanced ubiquitination of pro-apoptotic factors | PMID: 15616553 |
| Hepatocellular carcinoma | RNF7 upregulation correlates with poor prognosis and increased tumor growth | PMID: 23542377 |
| Colorectal cancer | RNF7 expression is elevated and associated with chemoresistance | PMID: 25482527 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Bone marrow | 8.5 | Medium |
| Brain | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.1 | Cervical cancer cell line |
| HEK293 | 12.4 | Embryonic kidney cell line |
| HepG2 | 11.8 | Hepatocellular carcinoma cell line |
| MCF7 | 9.2 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional effect |
| c.454G>A (p.Glu152Lys) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in RNF7.
Gain of Function (GOF)
Overexpression of wild-type RNF7 is associated with oncogenic properties; no activating mutations described.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (Reactome: R-HSA-983168)
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Apoptosis (KEGG: hsa04210)
Protein Summary
RNF7 is a 113-amino acid RING finger protein that acts as an E3 ubiquitin ligase component. It interacts with CUL1 and SKP1 to form the SCF complex, targeting proteins such as p27, cyclin D1, and Bcl-2 for ubiquitination and degradation. RNF7 is implicated in cell cycle control, apoptosis inhibition, and oxidative stress response. Its overexpression in various cancers suggests a role in tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF7 Knockout HEK293 Cell Line | EDJ-KQ6006 | Human | 9616 | Details Get a Quote |
| RNF7 Knockout A-549 Cell Line | EDJ-KQ30964 | Human | 9616 | Details Get a Quote |
| RNF7 Knockout HCT 116 Cell Line | EDJ-KQ30966 | Human | 9616 | Details Get a Quote |
| RNF7 Knockout HeLa Cell Line | EDJ-KQ30967 | Human | 9616 | Details Get a Quote |
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