RNF34: Ring Finger Protein 34
E3 ubiquitin-protein ligase involved in apoptosis, NF-kappa-B signaling, and cancer
Gene Information Card
| Symbol | RNF34 |
|---|---|
| Full Name | Ring Finger Protein 34 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 80196 ncbi.nlm.nih.gov/gene/80196 |
| Ensembl ID | ENSG00000111206 |
| UniProt ID | Q969K3 |
| OMIM ID | 610653 |
| HGNC ID | 16769 |
| Aliases | RIF, RNF34, FLJ20337, MGC13170 |
Description
RNF34 (Ring Finger Protein 34) encodes a RING finger domain-containing E3 ubiquitin ligase. The protein ubiquitinates target proteins, regulating apoptosis, NF-kappa-B signaling, and cell proliferation. It interacts with caspases and IAPs, modulating cell death pathways. Altered expression is linked to several cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | RNF34 overexpression inhibits apoptosis via ubiquitination of caspase-3 and caspase-7 | PMID: 19029910 |
| Breast cancer | RNF34 upregulation correlates with poor prognosis; promotes cell survival | PMID: 25605248 |
| Lung cancer | RNF34 knockdown reduces tumor growth in xenograft models | PMID: 27323852 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.1 | Medium |
| Lung | 9.7 | Low |
| Colon | 18.4 | Medium |
| Breast | 14.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 16.8 | Cervical cancer cell line |
| MCF7 | 22.1 | Breast cancer cell line |
| A549 | 13.5 | Lung cancer cell line |
| HCT116 | 19.3 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Pro146Leu) | Missense | <0.1% | Unknown functional impact |
| c.682G>A (p.Glu228Lys) | Missense | <0.1% | Reported in COSMIC; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
p.Glu228Lys may impair ubiquitin ligase activity
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• Apoptosis - multiple species (KEGG: hsa04210)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
Protein Summary
RNF34 is a 299-amino acid E3 ubiquitin ligase containing a RING-type zinc finger domain. It ubiquitinates caspases and other apoptotic regulators, promoting cell survival. The protein is localized to the cytoplasm and nucleus. Overexpression in cancers suggests an oncogenic role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF34 Knockout HEK293 Cell Line | EDJ-KQ9480 | Human | 80196 | Details Get a Quote |
| RNF34 Knockout HCT 116 Cell Line | EDJ-KQ34949 | Human | 80196 | Details Get a Quote |
| RNF34 Knockout A-549 Cell Line | EDJ-KQ36197 | Human | 80196 | Details Get a Quote |
| RNF34 Knockout HeLa Cell Line | EDJ-KQ36198 | Human | 80196 | Details Get a Quote |
