RNF215: Ring Finger Protein 215
A Gene Encoding a RING-Type E3 Ubiquitin Ligase with Emerging Roles in Cellular Regulation
Gene Information Card
| Symbol | RNF215 |
|---|---|
| Full Name | Ring Finger Protein 215 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q25.3 |
| NCBI Gene ID | 285498 ncbi.nlm.nih.gov/gene/285498 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q8N2E2 |
| OMIM ID | 618371 |
| HGNC ID | 26776 |
| Aliases | FLJ32709, MGC16384 |
Description
RNF215 (Ring Finger Protein 215) is a protein-coding gene located on chromosome 1q25.3. It encodes a RING-type zinc finger domain-containing protein predicted to function as an E3 ubiquitin ligase, mediating ubiquitination and subsequent proteasomal degradation of target proteins. The gene is expressed in multiple tissues and may play roles in cellular signaling and protein homeostasis. Limited functional characterization exists, but its domain architecture suggests involvement in ubiquitin-dependent regulatory pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association currently established | Not applicable | No curated evidence in OMIM, ClinVar, or COSMIC as of 2025 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.3 | Low |
| Adrenal gland | 7.1 | Low |
| Brain (cerebellum) | 6.4 | Low |
| Lung | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cell line |
| K562 | 8.7 | Leukemia cell line |
| HeLa | 7.3 | Cervical cancer cell line |
| HepG2 | 6.5 | Hepatocellular carcinoma cell line |
| A549 | 5.9 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants documented in curated databases.
Gain of Function (GOF)
No confirmed gain-of-function variants documented in curated databases.
Dominant Negative (DN)
No confirmed dominant-negative variants documented in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity (GO:0004842) | • zinc ion binding (GO:0008270) |
| • protein ubiquitination (GO:0016567) | • protein binding (GO:0005515) |
| • nucleus (GO:0005634) |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
Protein Summary
The RNF215 protein (UniProt Q8N2E2) contains a RING-type zinc finger domain characteristic of E3 ubiquitin ligases. It is predicted to localize to the nucleus and participate in ubiquitination of target proteins, marking them for degradation by the proteasome. The protein is 345 amino acids long with a molecular weight of approximately 39 kDa. Its specific substrates and biological functions remain largely uncharacterized, but its domain structure suggests a role in ubiquitin-dependent regulatory processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF215 Knockout HEK293 Cell Line | EDJ-KQ4451 | Human | 200312 | Details Get a Quote |
| RNF215 Knockout A-549 Cell Line | EDJ-KQ27003 | Human | 200312 | Details Get a Quote |
| RNF215 Knockout HCT 116 Cell Line | EDJ-KQ27004 | Human | 200312 | Details Get a Quote |
| RNF215 Knockout HeLa Cell Line | EDJ-KQ27005 | Human | 200312 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
