RNF208: Ring Finger Protein 208
A ubiquitin ligase with potential roles in cellular signaling and cancer
Gene Information Card
| Symbol | RNF208 |
|---|---|
| Full Name | ring finger protein 208 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 727800 ncbi.nlm.nih.gov/gene/727800 |
| Ensembl ID | ENSG00000188921 |
| UniProt ID | A6NNA2 |
| OMIM ID | - |
| HGNC ID | 26767 |
| Aliases | FLJ39660, MGC16384 |
Description
RNF208 (ring finger protein 208) is a protein-coding gene located on chromosome 9q34.3. The encoded protein contains a RING-type zinc finger domain characteristic of E3 ubiquitin ligases, suggesting a role in ubiquitination and protein degradation. RNF208 is expressed in various tissues and has been implicated in cancer biology, though its specific functions remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential dysregulation of ubiquitin-mediated proteolysis | Expression changes observed in tumor samples (COSMIC) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.1 | Low |
| Prostate | 2.8 | Low |
| Breast | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.0 | Low expression |
| HeLa | 1.2 | Not detected |
| MCF7 | 0.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity (GO:0004842) | • zinc ion binding (GO:0008270) |
| • protein ubiquitination (GO:0016567) |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
Protein Summary
RNF208 is a 208-amino acid protein containing a RING finger domain (C3HC4 type) at its N-terminus, which mediates E3 ubiquitin ligase activity. It is predicted to localize to the cytoplasm and nucleus. The protein may target specific substrates for ubiquitination, influencing cellular processes such as cell cycle and signal transduction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF208 Knockout HEK293 Cell Line | EDJ-KQ15107 | Human | 727800 | Details Get a Quote |
| RNF208 Knockout HCT 116 Cell Line | EDJ-KQ45693 | Human | 727800 | Details Get a Quote |
| RNF208 Knockout HeLa Cell Line | EDJ-KQ45694 | Human | 727800 | Details Get a Quote |
| RNF208 Knockout A-549 Cell Line | EDJ-KQ69152 | Human | 727800 | Details Get a Quote |
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