RNF167: Ring Finger Protein 167
E3 ubiquitin-protein ligase involved in endosomal trafficking and immune signaling
Gene Information Card
| Symbol | RNF167 |
|---|---|
| Full Name | Ring Finger Protein 167 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 26001 ncbi.nlm.nih.gov/gene/26001 |
| Ensembl ID | ENSG00000108576 |
| UniProt ID | Q9H6Y7 |
| OMIM ID | 616305 |
| HGNC ID | 23285 |
| Aliases | RING finger protein 167, FLJ10637, MGC138290 |
Description
RNF167 encodes a RING finger domain-containing E3 ubiquitin-protein ligase. The protein localizes to endosomes and the plasma membrane, where it ubiquitinates substrates involved in endosomal trafficking, receptor sorting, and immune signaling. RNF167 is implicated in the regulation of Toll-like receptor (TLR) signaling and autophagy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated disease entries in OMIM, ClinVar, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Lung | 6.5 | Low |
| Liver | 4.2 | Low |
| Kidney | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Moderate expression |
| HeLa | 8.9 | Moderate expression |
| K562 | 6.3 | Low expression |
| HepG2 | 5.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants curated | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity (GO:0004842) | • zinc ion binding (GO:0008270) |
| • integral component of membrane (GO:0016021) | • metal ion binding (GO:0046872) |
| • ubiquitin protein ligase activity (GO:0061630) | • endosome (GO:0005768) |
| • plasma membrane (GO:0005886) |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Endocytosis (KEGG: hsa04144)
Protein Summary
RNF167 is a 303-amino acid E3 ubiquitin ligase with a RING-type zinc finger domain. It mediates ubiquitination of target proteins, influencing their degradation or trafficking. The protein is anchored to membranes via a C-terminal transmembrane domain and is predominantly found in endosomes. Its activity modulates TLR signaling and endocytic recycling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF167 Knockout HEK293 Cell Line | EDJ-KQ2900 | Human | 26001 | Details Get a Quote |
| RNF167 Knockout A-549 Cell Line | EDJ-KQ23974 | Human | 26001 | Details Get a Quote |
| RNF167 Knockout HCT 116 Cell Line | EDJ-KQ23975 | Human | 26001 | Details Get a Quote |
| RNF167 Knockout HeLa Cell Line | EDJ-KQ22607 | Human | 26001 | Details Get a Quote |
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