RNF152
Ring Finger Protein 152: A Ubiquitin Ligase in Cellular Regulation
Gene Information Card
| Symbol | RNF152 |
|---|---|
| Full Name | ring finger protein 152 |
| Gene Type | protein coding |
| Chromosomal Location | 18q21.1 |
| NCBI Gene ID | 220441 ncbi.nlm.nih.gov/gene/220441 |
| Ensembl ID | ENSG00000176623 |
| UniProt ID | Q8N8N0 |
| OMIM ID | 616454 |
| HGNC ID | 28399 |
| Aliases | FLJ32642, MGC131891 |
Description
RNF152 (ring finger protein 152) is a protein-coding gene that encodes an E3 ubiquitin ligase. The protein contains a RING finger domain and is involved in ubiquitination and proteasomal degradation of target proteins. It plays roles in cellular processes including apoptosis, autophagy, and mTOR signaling regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | RNF152 may act as a tumor suppressor; altered expression or mutations could affect ubiquitination of oncogenic proteins. | COSMIC database reports somatic mutations in multiple cancer types. |
| Neurodegenerative disorders | Potential involvement via regulation of autophagy and protein aggregation pathways. | Limited evidence; inferred from functional studies. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 7.2 | Medium |
| Kidney | 6.8 | Medium |
| Liver | 5.1 | Low |
| Testis | 4.3 | Low |
| Lung | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.5 | High expression in embryonic kidney cells |
| HeLa | 6.2 | Moderate expression in cervical cancer cells |
| A549 | 4.8 | Low expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.454G>A (p.Glu152Lys) | Missense | <0.01% | Unknown; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not established; some missense mutations may impair E3 ligase activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Autophagy - animal (KEGG: hsa04140)
• mTOR signaling pathway (Reactome: R-HSA-165159)
Protein Summary
RNF152 is a 203-amino acid protein with a RING finger domain at the N-terminus (residues 30-72). It functions as an E3 ubiquitin ligase, catalyzing the transfer of ubiquitin to substrate proteins, leading to their degradation by the proteasome. The protein is localized in the cytoplasm and is involved in regulating autophagy and mTOR signaling. Its expression is moderate in brain and kidney tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF152 Knockout HEK293 Cell Line | EDJ-KQ1167 | Human | 220441 | Details Get a Quote |
| RNF152 Knockout HeLa Cell Line | EDJ-KQ59145 | Human | 220441 | Details Get a Quote |
| RNF152 Knockout A-549 Cell Line | EDJ-KQ67619 | Human | 220441 | Details Get a Quote |
| RNF152 Knockout HCT 116 Cell Line | EDJ-KQ76005 | Human | 220441 | Details Get a Quote |
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