RNF141 (Ring Finger Protein 141)
A zinc finger protein involved in ubiquitination and potential roles in cellular signaling and cancer.
Gene Information Card
| Symbol | RNF141 |
|---|---|
| Full Name | Ring Finger Protein 141 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 196472 ncbi.nlm.nih.gov/gene/196472 |
| Ensembl ID | ENSG00000166165 |
| UniProt ID | Q8N4W6 |
| OMIM ID | 616247 |
| HGNC ID | 25819 |
| Aliases | ZNF230, MGC13170 |
Description
RNF141 (Ring Finger Protein 141) encodes a protein containing a RING-type zinc finger domain, characteristic of E3 ubiquitin ligases. The protein is involved in ubiquitination and may play roles in protein degradation, signal transduction, and cell cycle regulation. Expression is observed in multiple tissues, with potential implications in cancer and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression or mutations may affect ubiquitination pathways, influencing tumorigenesis. | COSMIC database reports somatic mutations in various cancers. |
| No specific disease association in OMIM | Not established | OMIM entry 616247 notes no known disease association. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Lung | 2.8 | Low |
| Liver | 2.5 | Low |
| Kidney | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.5 | Embryonic kidney cells |
| HeLa | 3.8 | Cervical cancer cells |
| K562 | 3.2 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; effect unknown |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Rare variant; functional impact not characterized |
Mutation functional classification
Loss of Function (LOF)
Not established; no confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Not established; no evidence for gain-of-function mutations.
Dominant Negative (DN)
Not established; no known dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • ubiquitin-protein transferase activity (GO:0004842) | • protein ubiquitination (GO:0016567) |
| • nucleus (GO:0005634) |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
Protein Summary
RNF141 is a 366-amino acid protein with a RING finger domain at the N-terminus (residues 32-73). It functions as a putative E3 ubiquitin ligase, mediating ubiquitination of target proteins. The protein is localized to the nucleus and is expressed at low levels across tissues. Its precise biological roles remain under investigation, but it may contribute to cellular homeostasis and cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF141 Knockout HEK293 Cell Line | EDJ-KQ10118 | Human | 50862 | Details Get a Quote |
| RNF141 Knockout A-549 Cell Line | EDJ-KQ38498 | Human | 50862 | Details Get a Quote |
| RNF141 Knockout HCT 116 Cell Line | EDJ-KQ38499 | Human | 50862 | Details Get a Quote |
| RNF141 Knockout HeLa Cell Line | EDJ-KQ38500 | Human | 50862 | Details Get a Quote |
